Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery
Kristin Uth,Roger Sleigh +1 more
TLDR
Setting up the normal rhythm of the circadian cycle also involves oscillating changes in the chromatin structure, allowing differential activation of various chromatin domains within the 24-h cycle.Abstract:
Many physiological processes occur in a rhythmic fashion, consistent with a 24-h cycle. The central timing of the day/night rhythm is set by a master clock, located in the suprachiasmatic nucleus (a tiny region in the hypothalamus), but peripheral clocks exist in different tissues, adjustable by cues other than light (temperature, food, hormone stimulation, etc.), functioning autonomously to the master clock. Presence of unrepaired DNA damage may adjust the circadian clock so that the phase in which checking for damage and DNA repair normally occurs is advanced or extended. The expression of many of the genes coding for proteins functioning in DNA damage-associated response pathways and DNA repair is directly or indirectly regulated by the core clock proteins. Setting up the normal rhythm of the circadian cycle also involves oscillating changes in the chromatin structure, allowing differential activation of various chromatin domains within the 24-h cycle.read more
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Journal ArticleDOI
Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention
Michael H. Smolensky,Ramon C. Hermida,Alain Reinberg,Linda Sackett-Lundeen,Francesco Portaluppi +4 more
TL;DR: In 2001, Stevens and Rea coined the phrase “circadian disruption” (CD) to label the CTS misalignment induced by ALAN and shift work (SW) as a potential pathologic mechanism of the increased risk for cancer and other medical conditions.
Book ChapterDOI
Circadian Insights into Motivated Behavior.
TL;DR: The physiology of the circadian clock and its involvement in a number of motivated behaviors such as sleeping, eating, exercise, sexual behavior, and maternal behavior are explored.
Journal ArticleDOI
Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer
TL;DR: A complete understanding of the genetic and metabolic alterations in cancer must take potential circadian rhythm perturbations into account, as this disruption itself will influence how gene expression and metabolism are altered in the cancer cell compared to its non-transformed neighbor.
Journal ArticleDOI
Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota
Faraz Bishehsari,Abdulrahman Saadalla,Khashayarsha Khazaie,Phillip A. Engen,Robin M. Voigt,Brandon B. Shetuni,Christopher B. Forsyth,Maliha Shaikh,Martha Hotz Vitaterna,Fred W. Turek,Ali Keshavarzian +10 more
TL;DR: Circadian disruption by Light:dark shifting exacerbates alcohol-induced polyposis and CRC, and could, at least partly, be mediated by promoting a pro-tumorigenic inflammatory milieu via changes in microbiota.
Journal ArticleDOI
Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective.
TL;DR: Current knowledge on the role of the circadian clock and the contribution of omics-based approaches toward a novel precision health era for diagnosing and treating head and neck pathologies are discussed, with an emphasis on oral,Head and neck cancer and Sjögren's syndrome.
References
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Journal ArticleDOI
Combinatorial patterns of histone acetylations and methylations in the human genome
Zhibin Wang,Chongzhi Zang,Jeffrey A. Rosenfeld,Jeffrey A. Rosenfeld,Dustin E. Schones,Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Weiqun Peng,Michael Q. Zhang,Keji Zhao +11 more
TL;DR: The data suggest that a large number of histone modifications may act cooperatively to prepare chromatin for transcriptional activation and be associated with promoters and enhancers.
PatentDOI
Enchanced phosphorylation of P53 by ATM in response to DNA damage
TL;DR: A diagnostic tool for determining the presence of A-T having a detector for detecting ATMprotein levels and quantification tools for analyzing the ATM protein levels is also provided in this paper.
Journal ArticleDOI
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
Journal ArticleDOI
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
TL;DR: It is reported here that mice deficient in the mPer2 gene are cancer prone and suggested that the m per2 gene functions in tumor suppression by regulating DNA damage-responsive pathways.
Enhanced phosphorylation of p53 by ATN in response to DNA damage
Lilach Moyal,Shieh Sy,Y. Taya,L. Chessa,N. I. Smorodinsky,C. Prives,Y. Reiss,Y. Shiloh,Y. Ziv,C. W. Anderson,S. Banin +10 more
TL;DR: Various damage-induced responses may be activated by enhancement of the protein kinase activity of ATM, and this activity was markedly enhanced within minutes after treatment of cells with a radiomimetic drug.