Journal ArticleDOI
Designed Fabrication of Silica‐Based Nanostructured Particle Systems for Nanomedicine Applications
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TLDR
A survey of recent research progress on the fabrication strategies of these nanoparticle systems and their applications to medical diagnostics and therapy can be found in this article, where a number of different materials can be assembled on, encapsulated within, or integrated both inside and on the surface of silica nanoparticles using different chemistries and techniques.Abstract:
Suitably integrating multiple nanomaterials into nanostructured particle systems with specific combinations of properties has recently attracted significant attention in the research community. In particular, numerous particle systems have been designed and fabricated by integrating diverse materials with monodispersed silica nanoparticles. One or more distinct nanomaterials can be assembled on, encapsulated within, or integrated both inside and on the surface of silica nanoparticles using different chemistries and techniques to create multifunctional nanosystems. Research on these particle systems for biomedical applications has progressed rapidly during recent years due to the synergistic advantages of these complexes compared to the use of single components. This feature article surveys recent research progress on the fabrication strategies of these nanoparticle systems and their applications to medical diagnostics and therapy, thereby paving the way for the emerging field of nanomedicine.read more
Citations
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Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles
TL;DR: This review outlines the synthesis of MNPs of metal oxides and alloy sand then focuses on recent developments in the fabrication of MFMNPs of core/shell, dumbbell, and composite hybrid type and summarizes the general strategies applied for NP surface functionalization.
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Applications of advanced hybrid organic–inorganic nanomaterials: from laboratory to market
Clément Sanchez,Clément Sanchez,Philippe Belleville,Michael Popall,Lionel Nicole,Lionel Nicole +5 more
TL;DR: The description and discussion of the major applications of hybrid inorganic-organic (or biologic) materials are the major topic of this critical review.
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3.10 - Nitroxide-Mediated Polymerization
TL;DR: The main achievements in nitroxide-mediated polymerization (NMP) from its discovery to late 2010 are discussed in this paper, where various synthetic approaches to nitroxides and alkoxyamines are first presented.
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Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery
TL;DR: The latest research on the pathways of entry into live mammalian and plant cells together with intracellular trafficking are described, and the current research progress on the biocompatibility of this material in vitro and in vivo is discussed.
Journal ArticleDOI
Mesoporous silica nanoparticles in drug delivery and biomedical applications
Ying Wang,Qinfu Zhao,Ning Han,Ling Bai,Jia Li,Jia Liu,Erxi Che,Liang Hu,Qiang Zhang,Tongying Jiang,Siling Wang +10 more
TL;DR: A comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug Delivery systems.
References
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Journal ArticleDOI
Controlled growth of monodisperse silica spheres in the micron size range
TL;DR: In this article, a system of chemical reactions has been developed which permits the controlled growth of spherical silica particles of uniform size by means of hydrolysis of alkyl silicates and subsequent condensation of silicic acid in alcoholic solutions.
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Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
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Quantum dot bioconjugates for imaging, labelling and sensing
TL;DR: This review looks at current methods for preparing QD bioconjugates as well as presenting an overview of applications, and concludes that the potential of QDs in biology has just begun to be realized and new avenues will arise as the ability to manipulate these materials improves.