Journal ArticleDOI
Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression.
In-Sik Shin,Ju-Mi Hong,Ju-Mi Hong,Chan-Mi Jeon,Na-Rae Shin,Ok-Kyoung Kwon,Hui-Seong Kim,Hui-Seong Kim,Jong-Choon Kim,Sei-Ryang Oh,Kyung-Seop Ahn +10 more
TLDR
The effects of DADS on airway inflammation using an ovalbumin-induced model of allergic asthma and RAW264.7 cells suggest that DADS might represent a useful new oral therapy to treat allergic asthma.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-12-01. It has received 86 citations till now. The article focuses on the topics: Diallyl disulfide & Proinflammatory cytokine.read more
Citations
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Journal ArticleDOI
Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Rodrigo Arreola,Saray Quintero-Fabián,Rocío Ivette López-Roa,Enrique Octavio Flores-Gutierrez,Juan Pablo Reyes-Grajeda,Lucrecia Carrera-Quintanar,Daniel Ortuño-Sahagún +6 more
TL;DR: The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system as discussed by the authors.
Journal ArticleDOI
Chronic diseases, inflammation, and spices: how are they linked?
Ajaikumar B. Kunnumakkara,Bethsebie Lalduhsaki Sailo,Kishore Banik,Choudhary Harsha,Sahdeo Prasad,Subash C. Gupta,Alok C. Bharti,Bharat B. Aggarwal +7 more
TL;DR: The potential of various dietary agents such as spices and its components in the suppression of inflammatory pathways and their roles in the prevention and therapy of cancer and other chronic diseases are discussed.
Journal ArticleDOI
Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology
TL;DR: The biochemistry, metabolism, and signaling function of hydrogen sulfide, as well as its interplay with the other gasotransmitters, NO and CO, are reviewed.
Journal ArticleDOI
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases.
Samanta C. Funes,Mariana Ríos,Ayleen Fernández-Fierro,Camila Covián,Susan M. Bueno,Claudia A. Riedel,Juan Pablo Mackern-Oberti,Juan Pablo Mackern-Oberti,Alexis M. Kalergis +8 more
TL;DR: It is concluded that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health and opens a new outlook on the investigation of naturally derivedHO-1 inducers, mainly concerning autoimmunity.
Journal ArticleDOI
Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds.
Natalia Miękus,Krystian Marszałek,Magdalena Podlacha,Aamir Iqbal,Czesław Puchalski,Artur H. Świergiel +5 more
TL;DR: This review focuses on the two main sources of natural sulfur compounds: alliaceous and cruciferous vegetables and demonstrates that there is still a need to precisely demonstrate the bioavailability of sulfur-containing compounds from various types of functional food.
References
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Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
TL;DR: The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
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Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.
Christa Heussen,Eugene B. Dowdle +1 more
TL;DR: A new technique is described for the electrophoretic analysis of plasminogen activators in sodium dodecyl sulfate-polyacrylamide gels containing copolymerized pl asminogen and gelatin, which can be used to detect as little as 1 mU of urokinase and effectively distinguishes between melanoma- and u rokinase-type plasmineg activators.
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Characterization of the human cysteinyl leukotriene CysLT1 receptor.
Kevin R. Lynch,Gary P. O'Neill,Qingyun Liu,Dong Soon Im,Nicole Sawyer,Kathleen M. Metters,Nathalie Coulombe,Mark Abramovitz,David J. Figueroa,Zhizhen Zeng,Brett Connolly,Chang Bai,Christopher P. Austin,Anne Chateauneuf,Rino Stocco,Gillian Greig,Stacia Kargman,Shelley B. Hooks,E. Hosfield,David L. Williams,A. W. Ford-Hutchinson,C. T. Caskey,Jillian F. Evans +22 more
TL;DR: The molecular and pharmacological characterization of the cloned human CysLT1 receptor is reported and the functional activation (calcium mobilization) of this receptor is described by LTD4 and LTC4, and competition for radiolabelled LTD4 binding to this receptor by the cysteinyl leukotrienes and three structurally distinct classes of Cys LT1-receptor antagonists.
Journal ArticleDOI
Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential
TL;DR: This review covers how redox-dependent transcriptional activators such as NF-E2 related factor 2, NF2, NF-κB and AP-1 along with the transcription repressor BTB and CNC homologue 1 (Bach1) control the inducible HO-1 gene expression and the role of central pro- and anti-inflammatory cellular signaling cascades including p38 MAPK and phosphatidylinositol-3 kinase (PI3K)/
Journal ArticleDOI
Cholesterol-Lowering Effect of Garlic Extracts and Organosulfur Compounds: Human and Animal Studies
Yu-Yan Yeh,Lijuan Liu +1 more
TL;DR: The results of these studies indicate that the cholesterol-lowering effects of garlic extract, such as AGE, stem in part from inhibition of hepatic cholesterol synthesis by water-soluble sulfur compounds, especially SAC.