Journal ArticleDOI
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
Marco Radi,Federico Falchi,Anna Garbelli,Alberta Samuele,Vincenzo Bernardo,Stefania Paolucci,Fausto Baldanti,Silvia Schenone,Fabrizio Manetti,Giovanni Maga,Maurizio Botta,Maurizio Botta +11 more
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TLDR
The identification of the first small molecules specifically designed to inhibit the HIV-1 replication by targeting the RNA binding site of the human DEAD-Box RNA helicase DDX3 is described.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2012-03-01. It has received 83 citations till now. The article focuses on the topics: RNA Helicase A & RNA.read more
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Journal ArticleDOI
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Chantana Polprasert,Isabell Schulze,Mikkael A. Sekeres,Hideki Makishima,Bartlomiej P Przychodzen,Naoko Hosono,Jarnail Singh,Richard A. Padgett,Xiaorong Gu,James G. Phillips,Michael J. Clemente,Yvonne Parker,Daniel J. Lindner,Brittney Dienes,Eckhard Jankowsky,Yogen Saunthararajah,Yang Du,Kevin Oakley,Nhu Nguyen,Sudipto Mukherjee,Caroline Pabst,Lucy A. Godley,Jane E. Churpek,Daniel A. Pollyea,Utz Krug,Wolfgang E. Berdel,Hans-Ulrich Klein,Martin Dugas,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Kenichi Yoshida,Seishi Ogawa,Carsten Müller-Tidow,Carsten Müller-Tidow,Jaroslaw P. Maciejewski +36 more
TL;DR: An adult familial acute myeloid leukemia (AML) syndrome caused by germline mutations in the DEAD/H-box helicase gene DDX41 is described, suggesting that they constitute a family of tumor suppressor genes.
Journal ArticleDOI
DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication.
Anthony Fullam,Martina Schröder +1 more
TL;DR: In an interesting twist, a lot of DExD/H-box helicases have also been identified as essential host factors for the replication of different viruses, suggesting that viruses ‘hijack’ their RNA helicase activities for their benefit.
Journal ArticleDOI
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
TL;DR: The DEAD-box RNA helicase DDX3 is a multifunctional protein involved in all aspects of RNA metabolism, including transcription, splicing, mRNA nuclear export, translation, RNA decay and ribosome biogenesis, and could be a novel therapeutic target for the development of drug against HIV-1 and HCV.
Journal ArticleDOI
DDX3, a potential target for cancer treatment
TL;DR: There is concordance with in vitro evidence to support the hypothesis that DDX3 is associated with an aggressive phenotype in human malignancies, andDDX3 could be a druggable target for cancer treatment.
Journal ArticleDOI
Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
TL;DR: The current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics are reviewed.
References
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Journal ArticleDOI
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
Scott Wilhelm,Christopher A. Carter,Mark Lynch,Timothy B. Lowinger,Jacques Dumas,Roger A. Smith,Brian Schwartz,Ronit Simantov,Susan Kelley +8 more
TL;DR: The discovery and continuing development of sorafenib is described, the first oral multikinase inhibitor that targets Raf and affects tumour signalling and the tumour vasculature.
Journal ArticleDOI
The DEAD-box protein family of RNA helicases
TL;DR: The description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess gives insight into the regulation of ATP and RNA binding as well as in the ATPase and helicase activities.
Journal ArticleDOI
Requirement of DDX3 DEAD Box RNA Helicase for HIV-1 Rev-RRE Export Function
TL;DR: Evidence is presented that Rev/CRM1 activity utilizes the ATP-dependent DEAD box RNA helicase, DDX3, which functions in the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export.
Journal ArticleDOI
The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on mRNA
TL;DR: Comparison with the structure of the eIF4AIII-Btz subcomplex that is determined reveals that large conformational changes are required upon EJC assembly and disassembly.
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