Dosimetric characterisation and application to radiation biology of a kHz laser-driven electron beam
M. Cavallone,M. Cavallone,Lucas Rovige,Julius Huijts,Emilie Bayart,Rachel Delorme,Aline Vernier,Patrik Gonçalves Jorge,Raphaël Moeckli,Eric Deutsch,Jérôme Faure,Alessandro Flacco +11 more
TLDR
The dosimetric characterisation of a kHz, low energy laser-driven electron source and preliminary results on in-vitro irradiation of cancer cells are presented and validate the robustness of the dosimetry and irradiation protocol.Abstract:
Laser-plasma accelerators can produce ultra short electron bunches in the femtosecond to picosecond duration range, resulting in high peak dose rates in comparison with clinical accelerators. This peculiar characteristic motivates their application to radiation biology studies to elucidate the effect of the high peak dose rate on the biological response of living cells, which is still being debated. Electron beams driven by kHz laser systems may represent an attractive option for such applications, since the high repetition rate can boost the mean dose rate and improve the stability of the delivered dose in comparison with J-class laser accelerators running at 10 Hz. In this work, we present the dosimetric characterisation of a kHz, low energy laser-driven electron source and preliminary results on in-vitro irradiation of cancer cells. A shot-to-shot dosimetry protocol enabled to monitor the beam stability and the irradiation conditions for each cell sample. Results of survival assays on HCT116 colorectal cancer cells are in good agreement with previous findings reported in literature and validate the robustness of the dosimetry and irradiation protocol.read more
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Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy
Maria Grazia Ronga,Marco Cavallone,Annalisa Patriarca,A. M. M. Leite,Pierre Loap,Vincent Favaudon,Gilles Créhange,Ludovic De Marzi +7 more
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First theoretical determination of relative biological effectiveness of very high energy electrons.
Rachel Delorme,Rachel Delorme,Thongchai A. M. Masilela,Camille Etoh,François Smekens,Yolanda Prezado +5 more
TL;DR: In this paper, very high energy electrons (VHEEs) were compared with better known beams (clinical energy electrons, photons, protons, carbon and neon ions) using the modified micro-dosimetric kinetic model.
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Potential hazards and mitigation of X-ray radiation generated by laser-induced plasma from research-grade laser systems
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Transformative Technology for FLASH Radiation Therapy
Reinhard W. Schulte,Carol Johnstone,Salime Boucher,Eric Esarey,C. G. R. Geddes,Sergey Kutsaev,Billy W. Loo,Francois Méot,B. Mustapha,K. Nakamura,Emilio A. Nanni,Lieselotte Obst-Huebl,S.E. Sampayan,Carl Schroeder,Ke Sheng,Antoine M. Snijders,Emma Snively,Sami Tantawi,J. van Tilborg +18 more
TL;DR: In this paper , the authors proposed the FLASH radiation therapy (FLASH-RT), which is an ultra-high-dose-rate delivery of a therapeutic radiation dose within a fraction of a second.
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Carrier-envelope phase controlled dynamics of relativistic electron beams in a laser-wakefield accelerator
Lucas Rovige,Jos'ephine Monzac,J. V. Huijts,Igor Andriyash,Aline Vernier,Jaismeen Kaur,Marie Ouill'e,Zhao Cheng,Vidmantas Tomkus,Valdas Girdauskas,Gediminas Račiukaitis,Juozas Dudutis,Valdemar Stankevič,Paulius Gečys,Rodrigo Lopez-Martens,Jérôme Faure +15 more
TL;DR: In this article , the authors used near-single cycle laser pulses to drive a laser-wakefield accelerator and observed variations of electron beam pointing on the order of 10 mrad in the polarisation direction, as well as 30% variations of the beam charge, locked to the value of the controlled laser carrier-envelope phase.
References
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Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
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