Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia.
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TLDR
It is concluded that the present experimental conditions that primarily influence cholesterol and bile acid biosynthesis also affect the metabolism of plasma triglycerides-and presumably that of very low density lipoprotein-in a regulatory manner.About:
This article is published in Journal of Lipid Research.The article was published on 1978-11-01 and is currently open access. It has received 162 citations till now. The article focuses on the topics: Chenodeoxycholic acid & Cholestyramine.read more
Citations
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Journal ArticleDOI
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
Mitsuhiro Watanabe,Sander M. Houten,Li Wang,Antonio Moschetta,David J. Mangelsdorf,Richard A. Heyman,David D. Moore,Johan Auwerx,Johan Auwerx +8 more
TL;DR: The results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should be explored to correct hypertriglyceridemia.
Journal ArticleDOI
Targeting bile-acid signalling for metabolic diseases
TL;DR: How the signalling functions of bile acids can be exploited in the development of drugs for obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis, as well as other associated chronic diseases such as non-alcoholic steatohepatitis are reviewed.
OtherDOI
Bile Acid Metabolism and Signaling
TL;DR: Enterohepatic circulation of bile acids from the liver to intestine and back to the liver plays a central role in nutrient absorption and distribution, and metabolic regulation and homeostasis.
Journal ArticleDOI
Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation.
John D. Brunzell,Michael H. Davidson,Curt D. Furberg,Ronald B. Goldberg,Barbara V. Howard,James H. Stein,Joseph L. Witztum +6 more
TL;DR: It is unclear whether lipoprotein parameters other than LDL or non-HDL cholesterol provide clinically significant additional prognostic information regarding CVD risk, yield more information about the effectiveness of therapy, or indicate more appropriate treatment targets.
Journal ArticleDOI
Bile Acid Signaling in Metabolic Disease and Drug Therapy
Tiangang Li,John Y.L. Chiang +1 more
TL;DR: An interaction of liver bile acids and gut microbiota in the regulation of liver metabolism and potential therapeutic agents for treating metabolic diseases of the liver are revealed.
References
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Statistical Methods. 6th Edition.
Journal Article
Classification of hyperlipidaemias and hyperlipoproteinaemias.
TL;DR: The present memorandum presents a classification of the main types of hyperlipidaemia, based on lipoprotein analyses by electrophoresis and ultracentrifugation, and briefly describes the criteria for diagnosis as well as the methods of their determination.
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Effects of Weight Reduction on Obesity STUDIES OF LIPID AND CARBOHYDRATE METABOLISM IN NORMAL AND HYPERLIPOPROTEINEMIC SUBJECTS
TL;DR: In this article, the effects of weight loss on various aspects of carbohydrate and lipid metabolism in a group of 36 normal and hyperlipoproteinemic subjects were studied, with a direct relationship between the magnitude of the fall in plasma lipid values and the height of the initial plasma TG level.
Journal Article
Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism.
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Bile acid metabolism.
Danielsson H,Sjovall J +1 more
TL;DR: This chapter discusses the formation of Bile Acids, the use of Hydroxylation for Reduction, and the effects of diet and Vitamins and HORMONES on the synthesis of BILE Acids.