Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis.
Imad M. Tleyjeh,Zakariya Kashour,Moussab Damlaj,Moussab Damlaj,Muhammad Riaz,Haytham Tlayjeh,Haytham Tlayjeh,Mustafa Altannir,Youssef Altannir,Mohamad Al-Tannir,Rana Tleyjeh,Leslie C. Hassett,Tarek Kashour +12 more
TLDR
A living systematic review of the literature about the efficacy and toxicity of the IL-6 receptor antagonist, tocilizumab, in COVID-19 patients suggests that low risk of infections to high risk of adverse events is suggested to be lower than that of RCTs and observational studies at low or moderate risk of bias.About:
This article is published in Clinical Microbiology and Infection.The article was published on 2021-02-01 and is currently open access. It has received 152 citations till now. The article focuses on the topics: Randomized controlled trial & Tocilizumab.read more
Citations
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The first 12 months of COVID-19: a timeline of immunological insights.
TL;DR: A timeline of the major scientific discoveries during the first year of the COVID-19 pandemic showcases the collaborative efforts that enabled the key aspects of the immune response to SARS-CoV-2 to be reported at unprecedented speed.
Journal ArticleDOI
Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia.
André Santa Cruz,Ana Mendes-Frias,Ana Oliveira,Luís Dias,Ana Rita Matos,Alexandre Carvalho,Carlos Capela,Jorge Pedrosa,António G. Castro,Ricardo Silvestre +9 more
TL;DR: In this paper, the relationship between interleukin-1 (IL-1), IL-6, and IL-8, along with tumor necrosis factor alpha (TNFα) and other inflammatory mediators, was investigated in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Journal ArticleDOI
Interleukin-6 blocking agents for treating COVID-19: a living systematic review.
Lina Ghosn,Lina Ghosn,Anna Chaimani,Theodoros Evrenoglou,Mauricia Davidson,Mauricia Davidson,Carolina Graña,Carolina Graña,Christine Schmucker,Christine Schmucker,Claudia Bollig,Claudia Bollig,Nicholas Henschke,Yanina Sguassero,Camilla Hansen Nejstgaard,Camilla Hansen Nejstgaard,Sonia Menon,Sonia Menon,Thu Van Nguyen,Gabriel Ferrand,Gabriel Ferrand,Philipp Kapp,Philipp Kapp,Carolina Riveros,Carolina Riveros,Camila Ávila,Declan Devane,Declan Devane,Joerg J Meerpohl,Joerg J Meerpohl,Gabriel Rada,Asbjørn Hróbjartsson,Asbjørn Hróbjartsson,Giacomo Grasselli,Giacomo Grasselli,David Tovey,Philippe Ravaud,Philippe Ravaud,Isabelle Boutron,Isabelle Boutron +39 more
TL;DR: In this paper, the effect of interleukin 6 (IL-6) blocking agents compared to standard care alone or with placebo on efficacy and safety outcomes in severe coronavirus disease 2019 (COVID-19) was assessed.
Journal ArticleDOI
Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspects.
Giuseppe Lisco,A. De Tullio,Emilio Jirillo,Vito Angelo Giagulli,G. De Pergola,Edoardo Guastamacchia,Vincenzo Triggiani +6 more
TL;DR: In this article, the authors analyzed the relationship between COVID-19 and thyroid diseases from several perspectives and found that SARS-CoV-2 may induce thyroid dysfunction that is usually reversible, including subclinical and atypical thyroiditis.
Journal ArticleDOI
The acid sphingomyelinase/ceramide system in COVID-19.
TL;DR: In this article, the authors showed that SARS-CoV-2 uses these platforms for cell entry, and the addition of ceramide restored infection with SARS CoV2.
References
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The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +9 more
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