Journal ArticleDOI
Electrospun Fibrous PVDF-TrFe Scaffolds for Cardiac Tissue Engineering, Differentiation, and Maturation
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TLDR
The piezoelectric phenomenon is sought to be exploited, to measure the contractions generated by engineered cardiac tissues and it is demonstrated that human induced pluripotent stem cells can be directly seeded and differentiated to cardiomyocytes, and then mature over the course of 40 days on the PVDF fiber scaffolds.About:
This article is published in Advanced materials and technologies.The article was published on 2020-03-01. It has received 58 citations till now.read more
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Nanocomposite hydrogels for tissue engineering applications
TL;DR: Nanocomposite hydrogels, with its advantages of high mechanical property and some unique properties, have emerged as the most versatile and innovative technology, which provides a new opportunity as a unique tool for fabricating hydrogel with excellent properties in tissue engineering.
Journal ArticleDOI
Electroactive electrospun nanofibers for tissue engineering
Xiaodi Zhang,Xiaodi Zhang,Xiaodi Zhang,Longfei Li,Jiang Ouyang,Liqun Zhang,Jiajia Xue,Han Zhang,Wei Tao +8 more
TL;DR: The future direction of the design and functionalization of electroactive electrospun nanofibers for tissue engineering, and several promising strategies to make the scaffolds more intelligent, portable, monitorable, and safe are focused on.
Journal ArticleDOI
Piezoelectric nanogenerators for personalized healthcare.
TL;DR: The development of flexible piezoelectric nanogenerators has experienced rapid progress in the past decade and is serving as the technological foundation of future state-of-the-art personalized healthcare as mentioned in this paper .
Journal ArticleDOI
Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications
TL;DR: In this paper, the design rationale of electroactive biomaterials is discussed for imitating dynamic cell microenvironment, as well as their mediated electrostimulation and the applying pathways.
Journal ArticleDOI
Advances in Engineering Human Tissue Models.
TL;DR: In this paper, a review of 3D biomimetic cultures is presented, focusing on the technological bricks available to develop more physiologically relevant in vitro models of human tissues, including scaffold- or hydrogel-based formats, organotypic cultures, and organs-on-chips.
References
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Journal ArticleDOI
Electroactive phases of poly(vinylidene fluoride) : determination, processing and applications
TL;DR: In this article, the main characteristics of the electroactive phases of polyvinylidene fluoride and copolymers are summarized, and some interesting potential applications and processing challenges are discussed.
Journal ArticleDOI
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs : Evidence for a provisional safety margin in drug development
William S. Redfern,Leif Carlsson,A.S Davis,W G Lynch,I MacKenzie,S Palethorpe,Peter K. S. Siegl,I. Strang,A.T Sullivan,Rob Wallis,A. J. Camm,Tim Hammond +11 more
TL;DR: The dataset confirms the widely-held belief that most drugs associated with TdP in humans are also associated with hERG K(+) channel block at concentrations close to or superimposed upon the free plasma concentrations found in clinical use.
Journal ArticleDOI
High performance piezoelectric devices based on aligned arrays of nanofibers of poly(vinylidenefluoride-co-trifluoroethylene)
Luana Persano,Canan Dagdeviren,Yewang Su,Yewang Su,Yihui Zhang,Yihui Zhang,Salvatore Girardo,Dario Pisignano,Yonggang Huang,John A. Rogers +9 more
TL;DR: This work introduces a large area, flexible piezoelectric material that consists of sheets of electrospun fibres of the polymer poly[(vinylidenefluoride-co-trifluoroethylene] in order to enable ultra-high sensitivity for measuring pressure, even at exceptionally small values (0.1 Pa).
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Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Wolfram-Hubertus Zimmermann,Ivan Melnychenko,G Wasmeier,Michael Didié,Hiroshi Naito,Uwe Nixdorff,Andreas Hess,Lubos Budinsky,Kay Brune,Bjela Michaelis,Stefan Dhein,Alexander P. Schwoerer,Heimo Ehmke,Thomas Eschenhagen +13 more
TL;DR: This study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts.
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Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds.
Milica Radisic,Hyoungshin Park,Helen Shing,Thomas Consi,Frederick J. Schoen,Robert Langer,Lisa E. Freed,Gordana Vunjak-Novakovic +7 more
TL;DR: It is hypothesized that excitation–contraction coupling, critical for the development of a normal heart, determines the development and function of engineered myocardium.