Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TLDR
In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).Abstract:
In this work, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab-on-a-chip We report the results of experiments on aspects of sample processing, including on-chip preconcentration and dilution, on-chip sample injection or dispensing, and sample mixing It is shown that high speed transport and mixing of analytes and reagents can be performed using biological solutions without system contaminationread more
Citations
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Journal ArticleDOI
Digital microfluidics: is a true lab-on-a-chip possible?
TL;DR: To understand the opportunities and limitations of EWD microfluidics, this paper looks at the development of lab-on-chip applications in a hierarchical approach.
Patent
Droplet-based surface modification and washing
TL;DR: In this article, a method of splitting a droplet is provided, the method including providing a droplets microactuator including a single droplet including one or more beads and immobilizing at least one of the beads.
Journal ArticleDOI
High-level synthesis of digital microfluidic biochips
Fei Su,Krishnendu Chakrabarty +1 more
TL;DR: This work proposes a system design methodology that attempts to apply classical high-level synthesis techniques to the design of digital microfluidic biochips and develops an optimal scheduling strategy based on integer linear programming and two heuristic techniques that scale well for large problem instances.
Patent
Apparatuses and methods for manipulating droplets on a printed circuit board
TL;DR: The use of soldermask as an electrode insulator for droplet manipulation as well as techniques for adapting other traditional PCB layers and materials for droplets-based microfluidics are also disclosed in this article.
Journal ArticleDOI
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System
TL;DR: A polynomial-time algorithm for coordinating droplet movement under such hardware limitations is developed and described, and a layout-based system that can be rapidly reconfigured for new biochemical analyses is introduced.
References
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Proceedings ArticleDOI
Micro/nano liter droplet formation and dispensing by capacitance metering and electrowetting actuation
Hong Ren,Richard B. Fair +1 more
TL;DR: In this paper, a method is presented for dispensing droplets, which exploits the built-in capacitance of an electrowetting device to meter the droplet volume and control the dispensing process dynamically.