Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TLDR
In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).Abstract:
In this work, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab-on-a-chip We report the results of experiments on aspects of sample processing, including on-chip preconcentration and dilution, on-chip sample injection or dispensing, and sample mixing It is shown that high speed transport and mixing of analytes and reagents can be performed using biological solutions without system contaminationread more
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Patent
Droplet actuators, modified fluids and methods
TL;DR: In this article, the authors provide droplet actuators, modified fluids and methods relating to droplet operations, including a droplet operator, a filler fluid and an opening in the one or more physical barriers for transporting the droplet phase from one zone to another.
Proceedings ArticleDOI
Thermal effects on droplet transport in digital microfluidics with applications to chip cooling
TL;DR: In this paper, the effects of temperature-dependent system parameters on droplet transport in a digital microfluidics platform are investigated. But the authors do not address the problem of real-time active and smart cooling where hotter thermal regions (i.e., hot areas) are detected and subsequently cooled at an increased rate.
Proceedings ArticleDOI
A cross-referencing-based droplet manipulation method for high-throughput and pin-constrained digital microfluidic arrays
Tao Xu,Krishnendu Chakrabarty +1 more
TL;DR: A droplet manipulation method based on a "cross-referencing" addressing method that uses "row" and "columns" to access electrodes that allows simultaneous movement of a large number of droplets on a microfluidic array is proposed.
Patent
Bead manipulations on a droplet actuator
TL;DR: In this article, a droplet actuator consisting of a base substrate comprising electrodes configured for conducting droplet operations on the surface of the droplet and a barrier arranged in relation to the base substrate and the electrodes is described.
Patent
Droplet-Based Nucleic Acid Amplification in a Temperature Gradient
TL;DR: In this paper, a method of amplifying a nucleic acid, the method comprising cycling an amplification-ready droplet through a temperature gradient to locations within the temperature gradient suitable for effecting steps in an amplification reaction is described.
References
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Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Journal ArticleDOI
Light-driven motion of liquids on a photoresponsive surface
TL;DR: The light-driven motion of a fluid substance in a surface-modified glass tube suggests potential applicability to microscale chemical process systems.
Journal ArticleDOI
Electrochemical Principles for Active Control of Liquids on Submillimeter Scales
Benedict S. Gallardo,Vinay Gupta,Franklin D. Eagerton,Lana I. Jong,Vincent S. J. Craig,Rahul R. Shah,Nicholas L. Abbott +6 more
TL;DR: Electrochemical methods were combined with redox-active surfactants to actively control the motions and positions of aqueous and organic liquids on millimeter and smaller scales to guide droplets of organic liquids through simple fluidic networks.
Journal ArticleDOI
Dielectrophoretic liquid actuation and nanodroplet formation
TL;DR: In this article, the authors demonstrate a new class of high-speed DEP actuators, including wallless flowstructures, siphons, and nanodroplet dispensers that operate with water.
Journal ArticleDOI
Electrostatic actuation of liquid droplets for micro-reactor applications
TL;DR: In this paper, a device for the electrostatic actuation of liquid droplets on a solid surface is developed, where arrays of electrodes are micro-fabricated on a substrate, which is covered by a hydrophobic layer.