Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TLDR
In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).Abstract:
In this work, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab-on-a-chip We report the results of experiments on aspects of sample processing, including on-chip preconcentration and dilution, on-chip sample injection or dispensing, and sample mixing It is shown that high speed transport and mixing of analytes and reagents can be performed using biological solutions without system contaminationread more
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Patent
Microfluidic feedback using impedance detection
TL;DR: In this paper, the authors describe a processor, memory and code stored in the memory that when executed cause the processor at least to: receive an output voltage signal, superimpose an excitation signal onto the output voltage signals to produce a superimposed signal, connect the superimposition signal to an electrode in a droplet actuator, and measure the impedance of the electrode produced by the excitation signals, wherein the impedance indicates presence of liquid at the electrode.
Patent
Reagent storage on a droplet actuator
Jennifer Foley,Stefan Burde +1 more
TL;DR: In this paper, a method of providing a droplet comprising one or more reagents, the method comprising, depositing a first aqueous droplet, comprising the reagents on a surface; drying the droplet to yield a dried composition on the surface comprising the one or multiple reagents; covering the dried composition with oil; and causing a second aqueus in the oil to contact the dried mixture and thereby resuspend one or several reagents.
Journal ArticleDOI
Two-dimensional electrostatic actuation of droplets using a single electrode panel and development of disposable plastic film card
Eric Lebrasseur,Muhammad Imran Al-Haq,Wan-Kyu Choi,Masaaki Hirano,Hidenori Tsuchiya,Toru Torii,Toshiro Higuchi,Hiroki Yamazaki,Etsuo Shinohara +8 more
TL;DR: In this paper, the authors developed a device that can merge and transport microdroplets in two directions by electrostatic actuation technique, which uses only one electrode panel, based on standard printed circuit board, and in it, only 18 independent controls are needed.
Proceedings ArticleDOI
Design-for-Testability for Digital Microfluidic Biochips
Tao Xu,Krishnendu Chakrabarty +1 more
TL;DR: The concept of design-for-testability (DFT) for microfluidic biochips is introduced and a DFT method that incorporates a test plan into the fluidic operations of a target bioassay protocol is proposed that ensures a high level of testability.
Patent
Droplet actuation system and method
TL;DR: In this paper, a droplet actuation system is described, which includes a substrate that includes electrodes for conducting droplet operations, temperature control means for heating and cooling a region of the droplet, and a means for effecting a magnetic field in proximity to one or more of the electrodes sufficient to immobilize magnetically responsive beads.
References
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Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Journal ArticleDOI
Light-driven motion of liquids on a photoresponsive surface
TL;DR: The light-driven motion of a fluid substance in a surface-modified glass tube suggests potential applicability to microscale chemical process systems.
Journal ArticleDOI
Electrochemical Principles for Active Control of Liquids on Submillimeter Scales
Benedict S. Gallardo,Vinay Gupta,Franklin D. Eagerton,Lana I. Jong,Vincent S. J. Craig,Rahul R. Shah,Nicholas L. Abbott +6 more
TL;DR: Electrochemical methods were combined with redox-active surfactants to actively control the motions and positions of aqueous and organic liquids on millimeter and smaller scales to guide droplets of organic liquids through simple fluidic networks.
Journal ArticleDOI
Dielectrophoretic liquid actuation and nanodroplet formation
TL;DR: In this article, the authors demonstrate a new class of high-speed DEP actuators, including wallless flowstructures, siphons, and nanodroplet dispensers that operate with water.
Journal ArticleDOI
Electrostatic actuation of liquid droplets for micro-reactor applications
TL;DR: In this paper, a device for the electrostatic actuation of liquid droplets on a solid surface is developed, where arrays of electrodes are micro-fabricated on a substrate, which is covered by a hydrophobic layer.