Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TLDR
In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).Abstract:
In this work, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab-on-a-chip We report the results of experiments on aspects of sample processing, including on-chip preconcentration and dilution, on-chip sample injection or dispensing, and sample mixing It is shown that high speed transport and mixing of analytes and reagents can be performed using biological solutions without system contaminationread more
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Patent
Droplet operations platform
TL;DR: In this article, a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample is provided for conducting droplet operations, which may include a bottom substrate and a top substrate separated from each other to form a gap there between; an arrangement of droplet operation electrodes arranged on one or both of the bottom and/or top substrates for conducting liquid operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and openings arranged to provide a fluidic path from the one ormore compartments into the gap
Journal ArticleDOI
Fault Modeling and Functional Test Methods for Digital Microfluidic Biochips
Tao Xu,Krishnendu Chakrabarty +1 more
TL;DR: This paper addresses fundamental biochip operations, such as droplet dispensing, droplet transportation, mixing, splitting, and capacitive sensing, and evaluates the proposed test methods using simulations as well as experiments for a fabricated biochip.
Patent
Method of reducing liquid volume surrounding beads
TL;DR: In this paper, the authors described methods of concentrating beads in droplets, washing beads, methods of suspending beads, separating beads, localizing beads within a droplet, forming emulsions in which droplets include beads, loading beads into the gap of the droplet actuator, organizing beads in a monolayer, and capturing, trapping or restraining beads.
Proceedings ArticleDOI
Placement of digital microfluidic biochips using the t-tree formulation
TL;DR: This is the first work that adopts a topological representation to solve the placement problem of digital microfluidic biochips with a tree-based topological representations, called T-tree.
Patent
Bead incubation and washing on a droplet actuator
TL;DR: In this paper, the authors present methods for washing magnetically responsive beads using shape-assisted merging of droplets and shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magneticallyresponsive beads.
References
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Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Journal ArticleDOI
Light-driven motion of liquids on a photoresponsive surface
TL;DR: The light-driven motion of a fluid substance in a surface-modified glass tube suggests potential applicability to microscale chemical process systems.
Journal ArticleDOI
Electrochemical Principles for Active Control of Liquids on Submillimeter Scales
Benedict S. Gallardo,Vinay Gupta,Franklin D. Eagerton,Lana I. Jong,Vincent S. J. Craig,Rahul R. Shah,Nicholas L. Abbott +6 more
TL;DR: Electrochemical methods were combined with redox-active surfactants to actively control the motions and positions of aqueous and organic liquids on millimeter and smaller scales to guide droplets of organic liquids through simple fluidic networks.
Journal ArticleDOI
Dielectrophoretic liquid actuation and nanodroplet formation
TL;DR: In this article, the authors demonstrate a new class of high-speed DEP actuators, including wallless flowstructures, siphons, and nanodroplet dispensers that operate with water.
Journal ArticleDOI
Electrostatic actuation of liquid droplets for micro-reactor applications
TL;DR: In this paper, a device for the electrostatic actuation of liquid droplets on a solid surface is developed, where arrays of electrodes are micro-fabricated on a substrate, which is covered by a hydrophobic layer.