Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TLDR
In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).Abstract:
In this work, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab-on-a-chip We report the results of experiments on aspects of sample processing, including on-chip preconcentration and dilution, on-chip sample injection or dispensing, and sample mixing It is shown that high speed transport and mixing of analytes and reagents can be performed using biological solutions without system contaminationread more
Citations
More filters
Journal ArticleDOI
Energy minimization-based analysis of electrowetting for microelectronics cooling applications
TL;DR: The objective of the present work is to analyze the physics underlying two specific EW-based applications for microelectronics thermal management, targeted at hot-spot thermal management and relies on the control of droplet states on artificially structured surfaces through an applied EW voltage.
Proceedings ArticleDOI
ILP-based pin-count aware design methodology for microfluidic biochips
TL;DR: A comprehensive pin-constrained biochip design flow that addresses the pin-count issue at all design stages is presented, and exact ILP formulations and effective solution-space reduction schemes are proposed to minimize the assay time and pin count.
Patent
Methods for Manipulating Droplets by Electrowetting-Based Techniques
TL;DR: In this paper, the authors provided methods for manipulating droplets by placing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements.
Journal Article
Planar Microfluidic Drop Splitting and Merging
TL;DR: Laterally offset modulated surface acoustic waves (SAWs) were used in this article to split a drop into two equal sized droplets with an average deviation in their volumes of only around 4% and no greater than 10%, which is comparable to the 7% and below splitting deviation obtained with electrowetting drop splitting techniques.
Patent
Droplet-based nucleic acid amplification method and apparatus
TL;DR: In this paper, the authors describe a system including a droplet microactuator electronically coupled to and controlled by a processor capable of executing instructions, and a substrate comprising electrodes for conducting droplet operations.
References
More filters
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Journal ArticleDOI
Light-driven motion of liquids on a photoresponsive surface
TL;DR: The light-driven motion of a fluid substance in a surface-modified glass tube suggests potential applicability to microscale chemical process systems.
Journal ArticleDOI
Electrochemical Principles for Active Control of Liquids on Submillimeter Scales
Benedict S. Gallardo,Vinay Gupta,Franklin D. Eagerton,Lana I. Jong,Vincent S. J. Craig,Rahul R. Shah,Nicholas L. Abbott +6 more
TL;DR: Electrochemical methods were combined with redox-active surfactants to actively control the motions and positions of aqueous and organic liquids on millimeter and smaller scales to guide droplets of organic liquids through simple fluidic networks.
Journal ArticleDOI
Dielectrophoretic liquid actuation and nanodroplet formation
TL;DR: In this article, the authors demonstrate a new class of high-speed DEP actuators, including wallless flowstructures, siphons, and nanodroplet dispensers that operate with water.
Journal ArticleDOI
Electrostatic actuation of liquid droplets for micro-reactor applications
TL;DR: In this paper, a device for the electrostatic actuation of liquid droplets on a solid surface is developed, where arrays of electrodes are micro-fabricated on a substrate, which is covered by a hydrophobic layer.