Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TLDR
In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).Abstract:
In this work, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab-on-a-chip We report the results of experiments on aspects of sample processing, including on-chip preconcentration and dilution, on-chip sample injection or dispensing, and sample mixing It is shown that high speed transport and mixing of analytes and reagents can be performed using biological solutions without system contaminationread more
Citations
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Proceedings ArticleDOI
Defect aware droplet routing technique in digital microfluidic biochip
TL;DR: A heuristic approach of droplet routing by evading the defective electrode regions is proposed to minimize multiple usage of same resource, thus by reducing the probability of defects, or routing failure due to residual traces of several droplets.
Proceedings ArticleDOI
An Algorithm for Parallel Assay Operations in a Restricted Sized Chip in Digital Microfluidics
TL;DR: The paper presents a design automation flow that augments parallelism in applications considering cross contamination problem as well.
Proceedings ArticleDOI
Concepts for micropneumatic and microhydraulic logic gates
TL;DR: In this paper, the steady-state behavior of micro-pneumatic logic gates was studied and the transfer characteristic of these gates for switching between pneumatic states was derived.
Patent
Droplet actuators and techniques for droplet-based enzymatic assays
TL;DR: In this article, a method of conducting an assay comprises: incubating a droplet in oil, the droplet comprising an umbelliferone substrate, a sample potentially comprising an enzyme which cleaves the umbellified substrate, and a zwitterionic surfactant; and detecting a signal emitted from the cloud.
References
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Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Journal ArticleDOI
Light-driven motion of liquids on a photoresponsive surface
TL;DR: The light-driven motion of a fluid substance in a surface-modified glass tube suggests potential applicability to microscale chemical process systems.
Journal ArticleDOI
Electrochemical Principles for Active Control of Liquids on Submillimeter Scales
Benedict S. Gallardo,Vinay Gupta,Franklin D. Eagerton,Lana I. Jong,Vincent S. J. Craig,Rahul R. Shah,Nicholas L. Abbott +6 more
TL;DR: Electrochemical methods were combined with redox-active surfactants to actively control the motions and positions of aqueous and organic liquids on millimeter and smaller scales to guide droplets of organic liquids through simple fluidic networks.
Journal ArticleDOI
Dielectrophoretic liquid actuation and nanodroplet formation
TL;DR: In this article, the authors demonstrate a new class of high-speed DEP actuators, including wallless flowstructures, siphons, and nanodroplet dispensers that operate with water.
Journal ArticleDOI
Electrostatic actuation of liquid droplets for micro-reactor applications
TL;DR: In this paper, a device for the electrostatic actuation of liquid droplets on a solid surface is developed, where arrays of electrodes are micro-fabricated on a substrate, which is covered by a hydrophobic layer.