Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response
TLDR
From the distribution of Ld on the target cells, it is suggested that a single peptide-MHC complex per target cell can trigger activation of the T cell cytolytic response.About:
This article is published in Immunity.The article was published on 1996-06-01 and is currently open access. It has received 677 citations till now. The article focuses on the topics: Peptide/MHC Complex & T cell.read more
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Journal ArticleDOI
An immunogenic personal neoantigen vaccine for patients with melanoma
Patrick A. Ott,Zhuting Hu,Derin B. Keskin,Derin B. Keskin,Sachet A. Shukla,Sachet A. Shukla,Jing Sun,David J. Bozym,Wandi Zhang,Adrienne M. Luoma,Anita Giobbie-Hurder,Lauren Peter,Christina Chen,Oriol Olive,Todd A. Carter,Shuqiang Li,David J. Lieb,Thomas Eisenhaure,Evisa Gjini,Jonathan Stevens,William J. Lane,Indu Javeri,Kaliappanadar Nellaiappan,Andres M. Salazar,Heather Daley,Michael S. Seaman,Elizabeth I. Buchbinder,Elizabeth I. Buchbinder,Charles H. Yoon,Maegan Harden,Niall J. Lennon,Stacey Gabriel,Scott J. Rodig,Scott J. Rodig,Dan H. Barouch,Dan H. Barouch,Dan H. Barouch,Jon C. Aster,Jon C. Aster,Gad Getz,Gad Getz,Kai W. Wucherpfennig,Donna Neuberg,Jerome Ritz,Jerome Ritz,Eric S. Lander,Eric S. Lander,Edward F. Fritsch,Edward F. Fritsch,Nir Hacohen,Nir Hacohen,Catherine J. Wu +51 more
TL;DR: The feasibility, safety, and immunogenicity of a vaccine that targets up to 20 predicted personal tumour neoantigens is demonstrated and a strong rationale for further development of this approach, alone and in combination with checkpoint blockade or other immunotherapies is provided.
Book ChapterDOI
Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.
TL;DR: This important finding suggests that TAA-specific CTL may be present in some cancer patients but are unable to attack tumor cells due to the presence of inhibitory receptors.
Journal ArticleDOI
Pathways of Antigen Processing
TL;DR: This review highlights the aspects of MHC-I and M HC-II biosynthesis and assembly that have evolved to intersect these pathways and sample the peptides that are produced.
Journal ArticleDOI
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses.
TL;DR: Little is known about how immunodominant and subdominant determinants are distinguished by the TCD8+ repertoire, or how (and why) immunodomination occurs, but new tools are available to address these questions.
Journal ArticleDOI
T-cell regulation by CD28 and CTLA-4
TL;DR: Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28.
References
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Serial triggering of many T-cell receptors by a few peptide–MHC complexes
TL;DR: It is shown that a small number of peptideMHC complexes can achieve a high TCR occupancy, because a single complex can serially engage and trigger up to ∼200 TCRs.
Journal ArticleDOI
Evidence for a differential avidity model of T cell selection in the thymus
Philip G. Ashton-Rickardt,Antonio Bandeira,Joseph R. Delaney,Luc Van Kaer,Hanspeter Pircher,Rolf M. Zinkernagel,Susumu Tonegawa +6 more
TL;DR: A critical parameter that controls the fate of a thymocyte seems to be the number of TCRs engaged with complexes of peptide and major histocompatibility complex and when this number is low, positive selection occurs, and when it is high, negative selection takes place.
Journal ArticleDOI
Monoclonal antibodies for analysis of the HLA system.
TL;DR: III Antibodies A Monoclonal antibodies against determinants of the HLA-A,B,C glycoproteins and pjmicroglobulin and pJmicroglOBulin against species specific, non-polymorphic determinants 2.
Citation-classic - monoclonal-antibodies for analysis of the hla system
TL;DR: In this paper, a monoclonal antibody against determinants of the HLA-A,B,C glycoproteins and pjmicroglobulin was developed.
Journal ArticleDOI
Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
TL;DR: The number of specific complexes formed between peptide and the class II major histocompatibility complex (MHC) molecules expressed by an antigen-presenting cell (APC) after exposure to protein antigens is unknown, as is the number that activates T cells.