Fabrication and Characterization of Magnetic Microrobots for Three-Dimensional Cell Culture and Targeted Transportation
Sangwon Kim,Famin Qiu,Samhwan Kim,Ali Ghanbari,Cheil Moon,Li Zhang,Bradley J. Nelson,Bradley J. Nelson,Hongsoo Choi +8 more
Reads0
Chats0
TLDR
Three-dimensional porous structures fabricated with an SU-8 photoresist using a 3D laser lithography system for targeted cell transportation and human embryonic kidney 239 cells are cultivated in the microrobot.Abstract:
Magnetically manipulated microrobots are demonstrated for targeted cell transportation. Full three-dimensional (3D) porous structures are fabricated with an SU-8 photoresist using a 3D laser lithography system. Nickel and titanium are deposited as a magnetic material and biocompatible material, respectively. The fabricated microrobots are controlled in the fluid by external magnetic fields. Human embryonic kidney 239 (HEK 239) cells are cultivated in the microrobot to show the possibility for targeted cell transportation.read more
Citations
More filters
Journal ArticleDOI
Biomedical Applications of Untethered Mobile Milli/Microrobots
Metin Sitti,Metin Sitti,Hakan Ceylan,Wenqi Hu,Joshua Giltinan,Mehmet Turan,Sehyuk Yim,Eric Diller +7 more
TL;DR: A comprehensive review of the current advances in biomedical untethered mobile milli/microrobots and discusses the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.
Journal ArticleDOI
Controlled In Vivo Swimming of a Swarm of Bacteria‐Like Microrobotic Flagella
Ania Servant,Ania Servant,Famin Qiu,Mariarosa Mazza,Mariarosa Mazza,Kostas Kostarelos,Kostas Kostarelos,Bradley J. Nelson +7 more
TL;DR: In vivo imaging and actuation of a swarm of magnetic helical microswimmers by external magnetic fields in deep tissue is demonstrated for the first time, yielding a generation of micrometer-scale transporters with numerous applications in biomedicine including synthetic biology, assisted fertilization, and drug/gene delivery.
Journal ArticleDOI
Millimeter-scale flexible robots with programmable three-dimensional magnetization and motions
TL;DR: A method for patterning hard magnetic microparticles in an elastomer matrix based on ultraviolet (UV) lithography, which uses controlled reorientation of magnetic particles and selective exposure to UV light to encode magnetic particles in planar materials with arbitrary 3D orientation with a geometrical feature size as small as 100 micrometers.
Journal ArticleDOI
Fuel-Free Synthetic Micro-/Nanomachines.
TL;DR: Recent developments on fuel-free micro-/nanomotors (powered by various external stimuli such as light, magnetic, electric, or ultrasonic fields) are summarized, ranging from fabrication to propulsion mechanisms.
References
More filters
Journal ArticleDOI
In Vitro Oxygen Sensing Using Intraocular Microrobots
Olgaç Ergeneman,George Chatzipirpiridis,Juho Pokki,Marta Marín-Suárez,Georgios A. Sotiriou,Santiago Medina-Rodríguez,Jorge Fernando Fernandez Sanchez,Alberto Fernández-Gutiérrez,Salvador Pané,Bradley J. Nelson +9 more
TL;DR: A luminescence oxygen sensor integrated with a wireless intraocular microrobot for minimally-invasive diagnosis and an alternative sensor design with increased performance was demonstrated by using poly(styrene-co-maleic anhydride) (PS-MA) and PtOEP nanospheres.
Journal ArticleDOI
Direct laser writing and geometrical analysis of scaffolds with designed pore architecture for three-dimensional cell culturing
Elli Käpylä,Dogu Baran Aydogan,Sanni Virjula,Sari Vanhatupa,Susanna Miettinen,Jari Hyttinen,Minna Kellomäki +6 more
TL;DR: In this paper, the authors used two-photon polymerization (2PP) with a commercial polymer?ceramic material (Ormocomp?) for scaffold fabrication and showed that porosity values decreased up to 13% compared to the design specifications due to the fabrication process and shrinkage of the material.
Journal ArticleDOI
A Novel Swimming Microrobot Based on Artificial Cilia for Biomedical Applications
Ali Ghanbari,Mohsen Bahrami +1 more
TL;DR: A novel swimming microrobot inspired by ciliated microorganisms based on artificial cilia is introduced and performance parameters such as propulsive force, propulsive velocity and efficiency of the micRORobot are computed.
Journal ArticleDOI
Porous polysulfone coatings for enhanced drug delivery.
Kartik M. Sivaraman,Christoph R. Kellenberger,Salvador Pané,Olgaç Ergeneman,Tessa Lühmann,Norman A. Luechinger,Heike Hall,Wendelin J. Stark,Bradley J. Nelson +8 more
TL;DR: PSU can serve as a functional surface coating for drug delivery vehicles, such as intraocular biomicrorobots, and the straightforward synthesis and predictability of porosity enables the tuning of the amount of drug that can be loaded.
Journal ArticleDOI
Methodology for artificial microswimming using magnetic actuation
TL;DR: By solving the coupled magnetic-elastic-hydrodynamic problem, the proposed methodology for swimming at low-Reynolds-number flows based on ciliary motion of a microswimmer using magnetic actuation of artificial cilia can be used for devising biomedical microdevices that swim in viscous flows inside the human body.