Journal ArticleDOI
Functional connectivity of brain regions for self‐ and other‐evaluation in children, adolescents and adults with autism
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TLDR
Developmental differences in functional connectivity between areas underlying self- and other-referential thought may explain altered developmental trajectories in the understanding of self and others in individuals with ASD.Abstract:
Developing strong ties between oneself and others lays the foundation for developing social competence. Neuroimaging studies have consistently identified specific cortical midline regions activated during evaluative judgments about the self and others. Individuals with autism spectrum disorder (ASD) process self-relevant information differently from their peers, both behaviorally and at the neural level. We compared resting-state functional connectivity (rsFC) of regions involved in self-referential (e.g. medial prefrontal cortex; mPFC) and other-referential (e.g. posterior cingulate cortex; PCC) processing between neurotypical individuals and individuals with ASD in three age cohorts using regions of interest (ROIs) identified through an activation likelihood estimation meta-analysis. Typically developing children demonstrated greater connectivity within the midline self- and other-referential networks compared with age-matched children with ASD. No group differences in rsFC of mPFC or PCC emerged between typically developing adolescents and adolescents with ASD. Neurotypical adults exhibited stronger rsFC of the PCC with orbitofrontal cortex compared with adults with ASD. Developmental differences in functional connectivity between areas underlying self- and other-referential thought may explain altered developmental trajectories in the understanding of self and others in individuals with ASD.read more
Citations
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Journal ArticleDOI
A review of joint attention and social-cognitive brain systems in typical development and autism spectrum disorder.
TL;DR: Findings from this literature support and inform the hypothesis that the neurodevelopment of joint attention contributes to the functional development of neural systems for human social cognition, and have the potential to advance current models of social cognition and the social brain.
Journal ArticleDOI
Linking bodily, environmental and mental states in the self-A three-level model based on a meta-analysis.
TL;DR: There is a gradient organization in self-processing, through which body-environment information is integrated for the self via propagation from Interoceptive-processing to Mental-self-processing.
Journal ArticleDOI
Default mode hypoconnectivity underlies a sex-related autism spectrum
Rolf J. F. Ypma,Rachel L. Moseley,Rosemary Holt,Naresh Rughooputh,Dorothea L. Floris,Lindsay R. Chura,Michael D. Spencer,Simon Baron-Cohen,John Suckling,Edward T. Bullmore,Mikail Rubinov,Mikail Rubinov +11 more
TL;DR: Findings provide the first evidence for DMN hypoconnectivity as a behaviorally relevant neuroimaging phenotype of the sex-related spectrum of autistic traits, of which autism represents the extreme case.
Journal ArticleDOI
Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis
Wei Cheng,Edmund T. Rolls,Jie Zhang,Wenbo Sheng,Liang Ma,Lin Wan,Qiang Luo,Jianfeng Feng,Jianfeng Feng +8 more
TL;DR: A novel way of investigating how task‐ or function‐related networks have resting state functional connectivity differences in different psychiatric states, provides a new way to bridge the gap between task and resting‐state functional networks, and potentially helps to identify brain networks that might be treated.
Journal ArticleDOI
Shared atypical default mode and salience network functional connectivity between autism and schizophrenia.
Heng Chen,Lucina Q. Uddin,Xujun Duan,Junjie Zheng,Zhiliang Long,Youxue Zhang,Xiaonan Guo,Yan Zhang,Jingping Zhao,Huafu Chen +9 more
TL;DR: Some common neural mechanisms contributing to schizophrenia and ASD are suggested, and may aid in understanding the pathology of these two neurodevelopmental disorders.
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