Genomic imprinting: recognition and marking of imprinted loci.
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TLDR
Reports do not support the hypothesis that a sequence signature alone could distinguish imprinted regions from the rest of the genome, and it is becoming clear that features such as transcription, histone modifications and higher order chromatin are employed either individually or in combination to set up parental imprints.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 2012-04-01 and is currently open access. It has received 106 citations till now. The article focuses on the topics: Genomic imprinting & Differentially methylated regions.read more
Citations
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Journal ArticleDOI
Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
Lingjie Li,Bo Liu,Orly L. Wapinski,Miao-Chih Tsai,Kun Qu,Jiajing Zhang,Jeffrey C. Carlson,Meihong Lin,Fengqin Fang,Rajnish A. Gupta,Jill A. Helms,Howard Y. Chang +11 more
TL;DR: It is shown that targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones.
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Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment
Franck Court,Chiharu Tayama,Valeria Romanelli,Alex Martin-Trujillo,Isabel Iglesias-Platas,Kohji Okamura,Naoko Sugahara,Carlos Simón,Harry Moore,Julie V. Harness,Hans S. Keirstead,Jose V. Sanchez-Mut,Eisuke Kaneki,Pablo Lapunzina,Hidenobu Soejima,Norio Wake,Manel Esteller,Manel Esteller,Tsutomu Ogata,Kenichiro Hata,Kazuhiko Nakabayashi,David Monk +21 more
TL;DR: Pl placental-specific imprinting provides evidence for an inheritable epigenetic state that is independent of DNA methylation and the existence of a novel imprinting mechanism at these loci.
Journal ArticleDOI
DNA methylation dynamics during the mammalian life cycle
Jamie A. Hackett,M. Azim Surani +1 more
TL;DR: There is a better understanding of the mechanistic basis of DNA demethylation during epigenetic reprogramming in primordial germ cells and during pre-implantation development.
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Epigenetics, plasticity, and evolution: How do we link epigenetic change to phenotype?
TL;DR: Different types of epigenetic marks, their roles in gene expression and plasticity, methods for assaying epigenetic changes, and the future advances required to understand fully the impact of this field are discussed.
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Angelman syndrome: review of clinical and molecular aspects
TL;DR: There are four molecular classes of AS, and some genotype–phenotype correlations have emerged, and much remains to be understood regarding how insufficiency of E6-AP, the protein product of UBE3A, results in the observed neurodevelopmental deficits.
References
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Journal ArticleDOI
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.
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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.
Michael Weber,Ines Hellmann,Michael B. Stadler,Liliana Ramos,Svante Pääbo,Michael Rebhan,Dirk Schübeler +6 more
TL;DR: Results show that promoter sequence and gene function are major predictors of promoter methylation states and that inactive unmethylated CpG island promoters show elevated levels of dimethylation of Lys4 of histone H3, suggesting that this chromatin mark may protect DNA from methylation.
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Role for DNA methylation in genomic imprinting
TL;DR: It is demonstrated that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes in mutant mice that are deficient in DNA methyltransferase activity.
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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Steen K.T. Ooi,Chen Qiu,Emily Bernstein,Keqin Li,Da Jia,Zhe Yang,Hediye Erdjument-Bromage,Paul Tempst,Shau-Ping Lin,C. David Allis,Xiaodong Cheng,Timothy H. Bestor +11 more
TL;DR: DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2, and substitution of key residues in the binding site eliminated the H3 tail–DN MT3L interaction.
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Dnmt3L and the establishment of maternal genomic imprints.
TL;DR: Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally maternally methylated, and the defect was specific to imprinted regions, and global genome methylation levels were not affected.
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