Glia relay differentiation cues to coordinate neuronal development in Drosophila
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TLDR
A role for glia is identified in coordinating neuronal development across distinct brain regions, thus reconciling the timing of column assembly with that of delayed differentiation, as well as the spatiotemporal pattern of lamina neuron differentiation.Abstract:
Neuronal birth and specification must be coordinated across the developing brain to generate the neurons that constitute neural circuits. We used the Drosophila visual system to investigate how development is coordinated to establish retinotopy, a feature of all visual systems. Photoreceptors achieve retinotopy by inducing their target field in the optic lobe, the lamina neurons, with a secreted differentiation cue, epidermal growth factor (EGF). We find that communication between photoreceptors and lamina cells requires a signaling relay through glia. In response to photoreceptor-EGF, glia produce insulin-like peptides, which induce lamina neuronal differentiation. Our study identifies a role for glia in coordinating neuronal development across distinct brain regions, thus reconciling the timing of column assembly with that of delayed differentiation, as well as the spatiotemporal pattern of lamina neuron differentiation.read more
Citations
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Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival.
Ranjithmenon Muraleedharan,Mruniya V. Gawali,Deepak Tiwari,Abitha Sukumaran,Nicole Oatman,Jane Anderson,Diana Nardini,Mohammad Alfrad Nobel Bhuiyan,Ivan Tkáč,Amber L. Ward,Mondira Kundu,Ronald R. Waclaw,Ronald R. Waclaw,Lionel M L Chow,Christina Gross,Christina Gross,Raghavendra Rao,Stefanie Schirmeier,Biplab Dasgupta,Biplab Dasgupta +19 more
TL;DR: It is shown that the energy sensor AMP activated protein kinase (AMPK) regulates neuronal survival in a non-cell-autonomous manner and enables expression and surface translocation of the glucose transporter GLUT1, glucose uptake, and lactate production.
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