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Open AccessJournal ArticleDOI

Glial influence on the blood brain barrier.

Jorge I. Alvarez, +2 more
- 01 Dec 2013 - 
- Vol. 61, Iss: 12, pp 1939-1958
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TLDR
Recent findings related to the involvement of astrocytes and endothelial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood are described.
Abstract
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.

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Citations
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Trending Questions (1)
What is the brain, BBB and microglia?

The paper does not provide information about the brain or microglia. The paper is about the influence of glial cells on the blood brain barrier (BBB).