Glial influence on the blood brain barrier.
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TLDR
Recent findings related to the involvement of astrocytes and endothelial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood are described.Abstract:
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.read more
Citations
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The Blood–Brain Barrier
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Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits
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References
More filters
Journal ArticleDOI
Hedgehog signalling in vascular development.
TL;DR: The role of Hedgehog signalling in both embryonic and postnatal vascular development is reviewed and the temporal importance of a window of hedgehog dependent angiogenesis during development is emphasised and illustrated using a whole mouse embryo culture system.
Journal ArticleDOI
Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.
Xian Fan,Xian Fan,Bashar S. Staitieh,J. Spencer Jensen,Kara J. Mould,Jared A. Greenberg,Pratibha C. Joshi,Michael Koval,David M. Guidot,David M. Guidot +9 more
TL;DR: These new findings argue that HIV-1-related proteins downregulate Nrf2 expression and/or activity within the alveolar epithelium, which in turn impairs antioxidant defenses and barrier function, thereby rendering the lung susceptible to oxidative stress and injury.
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Shh Maintains Nkx2.1 in the MGE by a Gli3-Independent Mechanism
TL;DR: Examination of the evidence for distinct origins of interneuron subgroups and the role of the homeobox gene thyroid transcription factor1 (Ttf-1 or Nkx2.1) in the specification ofInterneuron specification from the medial ganglionic eminence (MGE) suggests factors regulating this gene can be critical determinants of the balance of excitation and inhibition in the postnatal cerebral cortex.
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B7 expression and antigen presentation by human brain endothelial cells: requirement for proinflammatory cytokines.
TL;DR: The data suggests that, although HBECs cannot alone support T cell proliferation and cytokine production,HBECs acting in concert with cytokines derived from a proinflammatory environment could support such a response.
Journal ArticleDOI
The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-κB Activation and Proinflammatory Gene Expression in Endothelial Cells
Andrea Sperone,Nicola H. Dryden,Graeme M. Birdsey,Leigh Madden,Michael M. Johns,Paul C. Evans,Justin C. Mason,Dorian O. Haskard,Joseph J. Boyle,Ewa M. Paleolog,Anna M. Randi +10 more
TL;DR: A novel physiological anti-inflammatory pathway under the control of the transcription factor Erg is identified; this pathway inhibits NF-&kgr;B–dependent transcription and TNF-&agr;–induced inflammation in vivo.