Glial influence on the blood brain barrier.
Reads0
Chats0
TLDR
Recent findings related to the involvement of astrocytes and endothelial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood are described.Abstract:
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.read more
Citations
More filters
Journal ArticleDOI
The Blood–Brain Barrier
Richard Daneman,Alexandre Prat +1 more
TL;DR: Understanding how these different cell populations interact to regulate the barrier properties is essential for understanding how the brain functions during health and disease.
Journal ArticleDOI
Astrocyte barriers to neurotoxic inflammation
TL;DR: Evidence that astrocytes have crucial roles in attracting and restricting CNS inflammation, with important implications for diverse CNS disorders is discussed.
Journal ArticleDOI
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
TL;DR: A deeper understanding of the BBB and BTB through the application of single-cell sequencing and imaging techniques, and the development of biomarkers of BBB integrity along with systems biology approaches, should enable new personalized treatment strategies for primary brain malignancies and brain metastases.
Journal ArticleDOI
Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits
Milos Pekny,Marcela Pekna +1 more
TL;DR: Understanding the multifaceted roles of astrocytes in the healthy and diseased CNS will undoubtedly contribute to the development of treatment strategies that will, in a context-dependent manner and at appropriate time points, modulate reactive astrogliosis to promote brain repair and reduce the neurological impairment.
Journal ArticleDOI
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment
O. van Tellingen,B. Yetkin-Arik,M.C. de Gooijer,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger,H.E. de Vries +7 more
TL;DR: Methods to overcome the blood-brain tumor barrier barrier (BBTB) are provided, including osmotic blood- brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor- mediated transport systems and physiological circumvention of the BBTB.
References
More filters
Journal ArticleDOI
VEGF expression is developmentally regulated during human brain angiogenesis.
Daniela Virgintino,Mariella Errede,David Robertson,Francesco Girolamo,A. Masciandaro,Bertossi M +5 more
TL;DR: The results show that in fetal human brain VEGF protein is located on multiple cell types, cells proper to the nervous tissue, neuroepithelial cells, neuroblasts and radial glia cells, and non-neuronal cells, endothelial and periendothelial cells that responds to the high metabolic demands of the differentiating neocortex.
Journal ArticleDOI
Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members
Ji Yeon Hong,Ji Yeon Hong,Jae Il Park,Kyucheol Cho,Kyucheol Cho,Dongmin Gu,Dongmin Gu,Hong Ji,Steven E. Artandi,Pierre D. McCrea,Pierre D. McCrea +10 more
TL;DR: It is reported that the degradation machinery of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating β-catin, and p120 stabilization increased its signaling activity in the context of the p120–Kaiso pathway.
Journal ArticleDOI
Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease
TL;DR: Bioluminescence from the brain and spinal cord correlates strongly with severity of clinical disease and a number of pathological changes in the brain in EAE and similar approaches could be applied to other animal models of autoimmune and inflammatory disorders.
Journal ArticleDOI
Functions of lipid raft membrane microdomains at the blood–brain barrier
Aurore Dodelet-Devillers,Romain Cayrol,Jack van Horssen,Arsalan S. Haqqani,Helga E. de Vries,Britta Engelhardt,John Greenwood,Alexandre Prat +7 more
TL;DR: The role of membrane microdomains, in particular lipid rafts, in the BBB under physiological conditions and during leukocyte transmigration/diapedesis is reviewed and a classification of endothelial membrane microDomains based on their function is proposed.
Journal ArticleDOI
Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema
Chun Fu Lien,Sarajo Kumar Mohanta,Małgorzata Frontczak-Baniewicz,Jerome D. Swinny,Barbara Zabłocka,Dariusz C. Górecki +5 more
TL;DR: It is shown that α-DB emerges as a central organizer of dystrophin-associated protein in glial endfeet and a rare example of a glial protein with a role in maintaining BBB function and its abnormalities might therefore lead to BBB dysfunction.