Glial influence on the blood brain barrier.
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TLDR
Recent findings related to the involvement of astrocytes and endothelial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood are described.Abstract:
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.read more
Citations
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Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
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Mechanisms of Pathogen Invasion into the Central Nervous System
TL;DR: Advances in understanding of the CNS invasion mechanisms of different neurotropic pathogens may enable the development of strategies to control their entry and deliver drugs to mitigate established infections.
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Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
Gulnaz Begum,Shanshan Song,Shaoxia Wang,Hanshu Zhao,Mohammad Iqbal H. Bhuiyan,Eric Li,Rachel Nepomuceno,Qing Ye,Ming Sun,Michael J. Calderon,Donna B. Stolz,Claudette M. St. Croix,Simon C. Watkins,Yinhuai Chen,Pingnian He,Gary E. Shull,Dandan Sun,Dandan Sun +17 more
TL;DR: Deletion of astrocytic Nhe1 gene significantly increased regional cerebral blood flow in the ischemic hemisphere at 24 hr post‐MCAO, providing the first line of evidence for a causative role of astroscopic NHE1 protein in reactive astrogliosis and isChemic neurovascular damage.
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Blood-brain barrier (BBB) and the complement landscape.
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In vitro models of molecular and nano-particle transport across the blood-brain barrier.
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TL;DR: A comprehensive understanding of bio-transport processes across the BBB in microfluidic devices is necessary to develop targeted and efficient therapies for a host of diseases ranging from neurological disorders to the spread of metastases in the brain.
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