Glial influence on the blood brain barrier.
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TLDR
Recent findings related to the involvement of astrocytes and endothelial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood are described.Abstract:
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.read more
Citations
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The Blood–Brain Barrier
Richard Daneman,Alexandre Prat +1 more
TL;DR: Understanding how these different cell populations interact to regulate the barrier properties is essential for understanding how the brain functions during health and disease.
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Astrocyte barriers to neurotoxic inflammation
TL;DR: Evidence that astrocytes have crucial roles in attracting and restricting CNS inflammation, with important implications for diverse CNS disorders is discussed.
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The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
TL;DR: A deeper understanding of the BBB and BTB through the application of single-cell sequencing and imaging techniques, and the development of biomarkers of BBB integrity along with systems biology approaches, should enable new personalized treatment strategies for primary brain malignancies and brain metastases.
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Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits
Milos Pekny,Marcela Pekna +1 more
TL;DR: Understanding the multifaceted roles of astrocytes in the healthy and diseased CNS will undoubtedly contribute to the development of treatment strategies that will, in a context-dependent manner and at appropriate time points, modulate reactive astrogliosis to promote brain repair and reduce the neurological impairment.
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Overcoming the blood-brain tumor barrier for effective glioblastoma treatment
O. van Tellingen,B. Yetkin-Arik,M.C. de Gooijer,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger,H.E. de Vries +7 more
TL;DR: Methods to overcome the blood-brain tumor barrier barrier (BBTB) are provided, including osmotic blood- brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor- mediated transport systems and physiological circumvention of the BBTB.
References
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The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms.
TL;DR: This review addresses current knowledge of the molecular trafficking signals involved in the migration of circulating leukocytes across the highly specialized blood-central nervous system (CNS) barriers during immunosurveillance and inflammation.
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Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis
TL;DR: An essential role for Wnt/β-catenin signaling in driving CNS-specific angiogenesis is revealed and molecular evidence thatAngiogenesis and BBB formation are in part linked is provided.
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Anna V. Molofsky,Robert Krenick,Erik M. Ullian,Hui-Hsin Tsai,Benjamin Deneen,William D. Richardson,Ben A. Barres,David H. Rowitch +7 more
TL;DR: It is proposed here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.