Journal ArticleDOI
Granulocyte Colony–Stimulating Factor Mobilizes CD34+ Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure
Vishal Garg,Hitendra Garg,Arshi Khan,Nirupama Trehanpati,Ashok Kumar,Barjesh Chander Sharma,Puja Sakhuja,Shiv Kumar Sarin +7 more
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TLDR
G-CSF therapy more than doubles the percentage of patients with ACLF who survive for 2 months; it also significantly reduces CTP, MELD, and SOFA scores and prevents the development of sepsis, hepatorenal syndrome, and hepatic encephalopathy.About:
This article is published in Gastroenterology.The article was published on 2012-03-01. It has received 294 citations till now. The article focuses on the topics: Model for End-Stage Liver Disease & Cirrhosis.read more
Citations
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Journal ArticleDOI
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis
Richard Moreau,Rajiv Jalan,Pere Ginès,Marco Pavesi,Paolo Angeli,Juan Córdoba,François Durand,Thierry Gustot,Faouzi Saliba,Marco Domenicali,Alexander L. Gerbes,Julia Wendon,Carlo Alessandria,Wim Laleman,Stefan Zeuzem,Jonel Trebicka,Mauro Bernardi,Vicente Arroyo +17 more
TL;DR: Diagnostic criteria for ACLF was established and showed that it is distinct from AD, based not only on the presence of organ failure(s) and high mortality rate but also on age, precipitating events, and systemic inflammation.
Journal ArticleDOI
Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Shiv Kumar Sarin,Manoj Kumar,George K. K. Lau,Zaigham Abbas,Henry Lik-Yuen Chan,Chien-Jen Chen,Ding-Shinn Chen,Huey-Ling Chen,Pei-Jer Chen,Rong-Nan Chien,Abdul Kadir Dokmeci,Edward Gane,J L Hou,Wasim Jafri,Jidong Jia,J. H. Kim,Ching-Lung Lai,Hon Cheung Lee,Seng Gee Lim,Chun-Jen Liu,Stephen Locarnini,M. Al Mahtab,Rosmawati Mohamed,Masao Omata,Jun Yong Park,Teerha Piratvisuth,Barjesh Chander Sharma,Jose D. Sollano,Fu-Sheng Wang,Lai Wei,Man-Fung Yuen,Shusen Zheng,Jia-Horng Kao +32 more
TL;DR: The final clinical practice guidelines and recommendations for the optimal management of chronic HBV infection are presented here, along with the relevant background information.
Journal ArticleDOI
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
Paolo Angeli,Mauro Bernardi,Càndid Villanueva,Claire Francoz,Rajeshwar P. Mookerjee,Jonel Trebicka,Aleksander Krag,Wim Laleman,Pere Ginès +8 more
TL;DR: The panel of experts, having emphasised the importance of initiating aetiologic treatment for any degree of hepatic disease at the earliest possible stage, extended its work to all the complications of cirrhosis which had not been covered by the European Association for the Study of the Liver guidelines.
Journal ArticleDOI
Acute-on chronic liver failure
Rajiv Jalan,Pere Ginès,Jody C. Olson,Rajeshwar P. Mookerjee,Richard Moreau,Guadalupe Garcia-Tsao,Vicente Arroyo,Patrick S. Kamath +7 more
TL;DR: In this paper, the authors focus on the current understanding of acute-on-chronic liver failure from the clinical, prognostic and pathophysiological perspectives and indicate potential biomarkers and therapeutic targets for intervention.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Management of alcohol-related liver disease
Mark Thursz,Antoni Gual,C. Lackner,Philippe Mathurin,Christophe Moreno,Laurent Spahr,Martina Sterneck,Helena Cortez-Pinto +7 more
TL;DR: The latest data on the treatment and management of alcohol-related liver disease will be reviewed and up to date recommendations for clinical management will be provided.
References
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Journal ArticleDOI
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)
Shiv Kumar Sarin,Ashok Kumar,John A. Almeida,Yogesh Chawla,Sheung Tat Fan,Hitendra Garg,H. Janaka de Silva,Saeed Hamid,Rajiv Jalan,Piyawat Komolmit,George K. K. Lau,Qing Liu,Kaushal Madan,Rosmawati Mohamed,Qin Ning,Salimur Rahman,Archana Rastogi,Stephen M. Riordan,Puja Sakhuja,Didier Samuel,Samir Shah,Barjesh Chander Sharma,Praveen Sharma,Yasuhiro Takikawa,Babu Ram Thapa,Chun-Tao Wai,Man-Fung Yuen +26 more
TL;DR: The original proposed definition of ACLF was found to withstand the test of time and identify a homogenous group of patients presenting with liver failure, which led to the development of the final AARC consensus.
Journal ArticleDOI
Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation
Alessandro M. Gianni,Marco Bregni,AngelikaC. Stern,Salvatore Siena,Corrado Tarella,Alessandro Pileri,Gianni Bonadonna +6 more
TL;DR: The rapid haematological recovery made possible by this approach promises to increase the therapeutic index of high-dose chemoradiotherapy regimens and to widen their role as treatment for chemoradiosensitive tumours.
Journal ArticleDOI
G-CSF Is an Essential Regulator of Neutrophil Trafficking from the Bone Marrow to the Blood
TL;DR: It is shown that under basal conditions granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil release from the bone marrow, and evidence is provided suggesting that downregulation of stromal cell-derived factor 1 expression in theBone marrow may represent such a signal.
Journal ArticleDOI
Heterogeneity and plasticity of hepatocyte lineage cells
TL;DR: Experimental models of liver injury and of hepatocarcinogenesis may call forth a cellular response at different levels in the hepatic lineage, and these cells have different potential to form cells of other types (plasticity).
Journal ArticleDOI
Plasticity of bone marrow-derived stem cells.
TL;DR: The literature that lends credibility to the theory that highly plastic BMCs have a role in maintenance and repair of nonhematopoietic tissue is reviewed and the possible mechanisms by which this may occur are discussed.
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