Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications
Dong-Wook Park,Amelia A. Schendel,Solomon Mikael,Sarah K. Brodnick,Thomas J. Richner,Jared P. Ness,Mohammed R. Hayat,Farid Atry,Seth Frye,Ramin Pashaie,Sanitta Thongpang,Zhenqiang Ma,Justin C. Williams +12 more
TLDR
An array of interfacing abilities of the CLEAR device are demonstrated and its utility for neural applications, including optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography.Abstract:
Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.read more
Citations
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A review on mechanics and mechanical properties of 2D materials—Graphene and beyond
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Ivan R. Minev,Pavel Musienko,Arthur Hirsch,Quentin Barraud,Nikolaus Wenger,Eduardo Martin Moraud,Jerome Gandar,Marco Capogrosso,Tomislav Milekovic,Leonie Asboth,Rafael Fajardo Torres,Nicolas Vachicouras,Nicolas Vachicouras,Qihan Liu,N. V. Pavlova,Simone Duis,Alexandre Larmagnac,Janos Vörös,Silvestro Micera,Silvestro Micera,Zhigang Suo,Grégoire Courtine,Stéphanie P. Lacour +22 more
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