Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
Diba Borgmann,Elisa Ciglieri,Nasim Biglari,Claus Brandt,Anna Lena Cremer,Heiko Backes,Marc Tittgemeyer,Marc Tittgemeyer,F. Thomas Wunderlich,Jens C. Brüning,Henning Fenselau,Henning Fenselau +11 more
TLDR
In this paper, intersectional genetic manipulations were employed to probe the feeding and glucoregulatory function of distinct sensory neurons, and it was shown that distinct gut-innervating sensory neurons differentially control feeding and glucose neurocircuits and may provide specific targets for metabolic control.About:
This article is published in Cell Metabolism.The article was published on 2021-07-06 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Sensory system & Stimulation.read more
Citations
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GLP-1 physiology informs the pharmacotherapy of obesity.
TL;DR: In this paper, the authors discuss the physiology of Glucagon-like peptide-1 (GLP-1) action in the control of food intake in animals and humans.
Journal ArticleDOI
GLP-1 physiology informs the pharmacotherapy of obesity
TL;DR: In this paper , the authors discuss the physiology of Glucagon-like peptide-1 (GLP-1) action in the control of food intake in animals and humans.
Journal ArticleDOI
Internal senses of the vagus nerve
TL;DR: A review of the state of knowledge related to vagal sensory neurons that innervate the respiratory, cardiovascular, and digestive systems can be found in this article , where the authors focus on cell types and their response properties, physiological/behavioral roles, engaged neural circuits and sensory receptors.
Journal ArticleDOI
Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus.
Alexander Jais,Jens C. Brüning +1 more
TL;DR: In this paper, the authors summarize novel insights with a particular emphasis on ARC neurocircuitries regulating food intake and glucose homeostasis and sensing factors that inform the brain of the organismal energy status.
Journal ArticleDOI
The physiological control of eating: signals, neurons, and networks
TL;DR: In this paper , the authors present a comprehensive and balanced assessment of how physiological signals associated with energy homeostasis interact at many brain levels to control eating behaviors, and discuss network models of how key regions in the endbrain (or telencephalon), hypothalamus, hindbrain, medulla, vagus nerve, and spinal cord work together with the gastrointestinal tract to enable the complex motor events that permit animals to eat in diverse situations.
References
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Journal ArticleDOI
The TTX‐Resistant Sodium Channel Nav1.8 (SNS/PN3): Expression and Correlation with Membrane Properties in Rat Nociceptive Primary Afferent Neurons
TL;DR: High levels of Nav1.8 protein may contribute to the longer AP durations (especially in A‐fibre neurons) and larger AP overshoots that are typical of nociceptors.
Journal ArticleDOI
Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig
T. Grhkn,Graham J. Dockray +1 more
TL;DR: Results provide direct evidence that calcitonin gene-related peptide is a marker for a major subset of visceral primary afferent neurons and suggest that this population of spinal afferents makes a major contribution to the total gastric content of calcitonIn gene- related peptide.
Journal ArticleDOI
Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor.
TL;DR: The vagal afferents to the rat fundus were anterogradely labeled in vivo with injections of the carbocyanine dye Dil into the nodose ganglia, and the nerves and ganglia of the enteric nervous system were labeled in toto with intraperitoneal Fluorogold injection.
Journal ArticleDOI
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.
Penny Y.T. Wang,Liora Caspi,Carol K.L. Lam,Madhu Chari,Xiaosong Li,Peter E. Light,Roger Gutierrez-Juarez,Michelle Ang,Gary J. Schwartz,Tony K.T. Lam,Tony K.T. Lam +10 more
TL;DR: It is demonstrated that direct administration of lipids into the upper intestine increased upper intestinal long-chain fatty acyl-coenzyme A levels and suppressed glucose production, indicating that upper intestinal LCFA-CoAs regulate glucose production in the preabsorptive state.
Journal ArticleDOI
Vagal Sensory Neuron Subtypes that Differentially Control Breathing.
TL;DR: The vagus nerve contains intermingled sensory neurons constituting genetically definable labeled lines with different anatomical connections and physiological roles, which reveal that these neurons densely innervate the lung and send long-range projections to different brainstem targets.
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