Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
Diba Borgmann,Elisa Ciglieri,Nasim Biglari,Claus Brandt,Anna Lena Cremer,Heiko Backes,Marc Tittgemeyer,Marc Tittgemeyer,F. Thomas Wunderlich,Jens C. Brüning,Henning Fenselau,Henning Fenselau +11 more
TLDR
In this paper, intersectional genetic manipulations were employed to probe the feeding and glucoregulatory function of distinct sensory neurons, and it was shown that distinct gut-innervating sensory neurons differentially control feeding and glucose neurocircuits and may provide specific targets for metabolic control.About:
This article is published in Cell Metabolism.The article was published on 2021-07-06 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Sensory system & Stimulation.read more
Citations
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Association of residual feed intake with intestinal microbiome and metabolome in laying period of ducks
TL;DR: In this article , the authors explored the relationship between intestinal microbiome and metabolome of ducks with different residual feed intake during the laying period, and provided theoretical basis for further study on the relationship.
Posted ContentDOI
Effect of duodenal-jejunal bypass on diabetes in the early postoperative period
TL;DR: In this article , the effect of duodenal-jejunal bypass (DJB) in a rat model of type 2 diabetes mellitus during the early postoperative period was investigated.
Posted ContentDOI
Asymmetric control of food intake by left and right vagal sensory neurons
Alan de Araujo,Isadora M Braga,Gabriel Leme,Arashdeep Singh,M. McDougle,Justin A. Smith,Macarena Vergara,Habibeh Khoshbouei,Eric G. Krause,A. G. de Oliveira,Guillaume de Lartigue +10 more
TL;DR: The hypothesis is that LNGCart and RNGCART neurons sense different meal‐related signals and are necessary and sufficient to modulate feeding.
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Clarifying the effect of gut microbiota on allergic conjunctivitis risk is instrumental for predictive, preventive, and personalized medicine: a Mendelian randomization analysis
TL;DR: Wang et al. as mentioned in this paper found that individuals with microbial dysbiosis may be more susceptible to allergic conjunctivitis due to an increased inflammatory response, and they used the robust adjusted profile score (MR) to identify allergic-related gut microbes.
References
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Journal ArticleDOI
NIH Image to ImageJ: 25 years of image analysis
TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
Journal ArticleDOI
Central nervous system control of food intake
TL;DR: A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
Journal ArticleDOI
Globally optimal stitching of tiled 3D microscopic image acquisitions
TL;DR: This work developed a method that, based on the Fourier Shift Theorem, computes all possible translations between pairs of 3D images, yielding the best overlap in terms of the cross-correlation measure and subsequently finds the globally optimal configuration of the whole group of3D images.
Journal ArticleDOI
A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex
Hiroki Taniguchi,Miao He,Priscilla Wu,Sangyong Kim,Raehum Paik,Ken Sugino,Duda Kvitsani,Yu Fu,Jiangteng Lu,Ying Lin,Goichi Miyoshi,Yasuyuki Shima,Gord Fishell,Sacha B. Nelson,Z. Josh Huang +14 more
TL;DR: Using genetic engineering in mice, approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons are generated, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior.
Journal ArticleDOI
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Dmitry Usoskin,Alessandro Furlan,Saiful Islam,Hind Abdo,Peter Lönnerberg,Daohua Lou,Jens Hjerling-Leffler,Jesper Z. Haeggström,Olga Kharchenko,Peter V. Kharchenko,Sten Linnarsson,Patrik Ernfors +11 more
TL;DR: The results suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a distinct itch-generating type, and demonstrate single-cell RNA-seq as an effective strategy for dissecting sensory responsive cells into distinct neuronal types.
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