Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
Diba Borgmann,Elisa Ciglieri,Nasim Biglari,Claus Brandt,Anna Lena Cremer,Heiko Backes,Marc Tittgemeyer,Marc Tittgemeyer,F. Thomas Wunderlich,Jens C. Brüning,Henning Fenselau,Henning Fenselau +11 more
TLDR
In this paper, intersectional genetic manipulations were employed to probe the feeding and glucoregulatory function of distinct sensory neurons, and it was shown that distinct gut-innervating sensory neurons differentially control feeding and glucose neurocircuits and may provide specific targets for metabolic control.About:
This article is published in Cell Metabolism.The article was published on 2021-07-06 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Sensory system & Stimulation.read more
Citations
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The Metabolic Role and Therapeutic Potential of the Microbiome
TL;DR: How the gut bacterial composition is altered in, and can contribute to, cardiometabolic disease, as well as how the gut bacteria can be targeted to treat and prevent metabolic diseases are discussed.
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Neural signalling of gut mechanosensation in ingestive and digestive processes
TL;DR: Current understanding of the generation of mechanosensory signals from the digestive periphery, the neural afferent pathways that relay these signals to the brain and the neural circuit mechanisms that control ingestive and digestive processes are discussed, focusing on the four major digestive tract parts.
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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation
TL;DR: In this article , the authors employed a combination of neuroanatomical, genetic, and behavioral approaches in the mouse to investigate the involvement of caudal brainstem cholecystokinin-expressing neurons in the effect of the GLP-1RA exendin-4.
Journal ArticleDOI
Neural signalling of gut mechanosensation in ingestive and digestive processes
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Technical Note: Modulation of fMRI brainstem responses by transcutaneous vagus nerve stimulation.
Diba Borgmann,Lionel Rigoux,Bojana Kuzmanovic,Sharmili Edwin Thanarajah,Thomas F. Münte,Henning Fenselau,Marc Tittgemeyer +6 more
TL;DR: In this article, a transcutaneous auricular VNS (taVNS) was applied during task-free fMRI in a single-blinded crossover design to examine time-dependent effects of taVNS on brainstem neuronal responses in healthy human subjects.
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Dmitry Usoskin,Alessandro Furlan,Saiful Islam,Hind Abdo,Peter Lönnerberg,Daohua Lou,Jens Hjerling-Leffler,Jesper Z. Haeggström,Olga Kharchenko,Peter V. Kharchenko,Sten Linnarsson,Patrik Ernfors +11 more
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