Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
Diba Borgmann,Elisa Ciglieri,Nasim Biglari,Claus Brandt,Anna Lena Cremer,Heiko Backes,Marc Tittgemeyer,Marc Tittgemeyer,F. Thomas Wunderlich,Jens C. Brüning,Henning Fenselau,Henning Fenselau +11 more
TLDR
In this paper, intersectional genetic manipulations were employed to probe the feeding and glucoregulatory function of distinct sensory neurons, and it was shown that distinct gut-innervating sensory neurons differentially control feeding and glucose neurocircuits and may provide specific targets for metabolic control.About:
This article is published in Cell Metabolism.The article was published on 2021-07-06 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Sensory system & Stimulation.read more
Citations
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GLP-1 physiology informs the pharmacotherapy of obesity.
TL;DR: In this paper, the authors discuss the physiology of Glucagon-like peptide-1 (GLP-1) action in the control of food intake in animals and humans.
Journal ArticleDOI
GLP-1 physiology informs the pharmacotherapy of obesity
TL;DR: In this paper , the authors discuss the physiology of Glucagon-like peptide-1 (GLP-1) action in the control of food intake in animals and humans.
Journal ArticleDOI
Internal senses of the vagus nerve
TL;DR: A review of the state of knowledge related to vagal sensory neurons that innervate the respiratory, cardiovascular, and digestive systems can be found in this article , where the authors focus on cell types and their response properties, physiological/behavioral roles, engaged neural circuits and sensory receptors.
Journal ArticleDOI
Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus.
Alexander Jais,Jens C. Brüning +1 more
TL;DR: In this paper, the authors summarize novel insights with a particular emphasis on ARC neurocircuitries regulating food intake and glucose homeostasis and sensing factors that inform the brain of the organismal energy status.
Journal ArticleDOI
The physiological control of eating: signals, neurons, and networks
TL;DR: In this paper , the authors present a comprehensive and balanced assessment of how physiological signals associated with energy homeostasis interact at many brain levels to control eating behaviors, and discuss network models of how key regions in the endbrain (or telencephalon), hypothalamus, hindbrain, medulla, vagus nerve, and spinal cord work together with the gastrointestinal tract to enable the complex motor events that permit animals to eat in diverse situations.
References
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Journal ArticleDOI
Gut-Brain Glucose Signaling in Energy Homeostasis
Maud Soty,Maud Soty,Amandine Gautier-Stein,Amandine Gautier-Stein,Fabienne Rajas,Fabienne Rajas,Gilles Mithieux,Gilles Mithieux +7 more
TL;DR: This work raises several questions relating to the conditions under which intestinal gluconeogenesis proceeds and may provide its metabolic benefits and also leads to questions on the advantage conferred by its conservation through a process of natural selection.
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Signalling from the periphery to the brain that regulates energy homeostasis.
TL;DR: This work has identified target hindbrain neurocircuitry that integrates the orchestration of individual bouts of ingestion with the long-term regulation of energy balance.
Journal ArticleDOI
Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms
Kristoffer L. Egerod,Natalia Petersen,Pascal Timshel,Jens C. Rekling,Yibing Wang,Qinghua Liu,Thue W. Schwartz,Laurent Gautron +7 more
TL;DR: This study provides a comprehensive description of GPCR-dependent sensing mechanisms in vagal afferents, including novel coexpression patterns, and conceivably coaction of key receptors for gut-derived molecules involved in gut-brain communication.
Journal ArticleDOI
Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract: anatomical identification and functional integrity
TL;DR: It is concluded that among primary vagal afferents there is a capsaicin-resistant population that primarily innervates the esophagus and upper gastrointestinal tract, and a capsicin-sensitive population that innervate mainly the lower tract.
Journal ArticleDOI
High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men
Kathryn A. Boyd,Deirdre O'Donovan,Selena Doran,Judith M. Wishart,Ian Chapman,Michael Horowitz,Christine Feinle +6 more
TL;DR: Exposure to an HF diet for 14 days attenuates the effects of duodenal lipid on antropyloroduodanal pressures and hunger without affecting food intake or plasma hormone levels.
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