High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams
Michael J. Nasse,Michael J. Walsh,Eric C. Mattson,Ruben Reininger,Andre Kajdacsy-Balla,Virgilia Macias,Rohit Bhargava,Carol J. Hirschmugl +7 more
TLDR
This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.Abstract:
Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.read more
Citations
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Advances in optical biopsy – correlation of malignancy and cell density of primary brain tumors using Raman microspectroscopic imaging
Christoph Krafft,Birhanu Belay,Norbert Bergner,Bernd F. M. Romeike,Rupert Reichart,Rolf Kalff,Jürgen Popp +6 more
TL;DR: The results demonstrate how morphology and chemical composition obtained by Raman imaging correlate with histopathology and provide complementary, diagnostically relevant information at the cellular level.
Journal ArticleDOI
FTIR imaging, a useful method for studying the compatibility of silk fibroin-based polymer blends
TL;DR: In this paper, the authors used FTIR imaging to study the phase behavior of three silk protein-based polymer blends, including Silk Fibroin/chitosan (SF/CS), Silk Fibrosin/sodium alginate (SSA), Silk fibroin and polyvinyl alcohol (PVA), and Silk fibrosin and pVA.
Journal ArticleDOI
The Use of Synchrotron Radiation for the Characterization of Artists' Pigments and Paintings
Koen Janssens,Matthias Alfeld,Geert Van der Snickt,Wout De Nolf,Frederik Vanmeert,Marie Radepont,Letizia Monico,Joris Dik,Marine Cotte,Gerald Falkenberg,Costanza Miliani,Brunetto Giovanni Brunetti +11 more
TL;DR: Methods and recent studies in which macroscopic to (sub)microscopic X-ray beams were used for nondestructive analysis and characterization of pigments, paint microsamples, and/or entire paintings are reviewed.
Journal ArticleDOI
Synchrotron infrared measurements of protein phosphorylation in living single PC12 cells during neuronal differentiation.
Liang Chen,Hoi-Ying N. Holman,Zhao Hao,Hans A. Bechtel,Michael C. Martin,Chengbiao Wu,Steven Chu +6 more
TL;DR: Evidence is provided that protein phosphorylation in individual living mammalian cells can be measured with synchrotron radiation-based Fourier transform-infrared (SR-FT-IR) spectromicroscopy, and the multimolecule sensitivity of this technique will be useful for unraveling the associated molecular changes during cellular signaling and response processes.
Journal ArticleDOI
Two-Dimensional Correlation Spectroscopy for Multimodal Analysis of FT-IR, Raman, and MALDI-TOF MS Hyperspectral Images with Hamster Brain Tissue
Peter Lasch,Isao Noda +1 more
TL;DR: Two-dimensional correlation spectroscopy (2DCOS) is introduced as a novel technique for jointly analyzing HSI data which allows one to obtain deeper insights into the chemistry of complex samples by decrypting auto- and heterospectral correlations that may exist between features of the different H SI data.
References
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Dirac charge dynamics in graphene by infrared spectroscopy
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