High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams
Michael J. Nasse,Michael J. Walsh,Eric C. Mattson,Ruben Reininger,Andre Kajdacsy-Balla,Virgilia Macias,Rohit Bhargava,Carol J. Hirschmugl +7 more
TLDR
This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.Abstract:
Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.read more
Citations
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Chemically imaging the effects of the addition of nanofibrillated cellulose on the distribution of poly(acrylic acid) in poly(vinyl alcohol)
Craig M. Clemons,Julia Sedlmair,Julia Sedlmair,Julia Sedlmair,Barbara L. Illman,Barbara L. Illman,Rebecca E. Ibach,Carol J. Hirschmugl,Carol J. Hirschmugl +8 more
TL;DR: In this article, the distribution of poly(acrylic acid) in model laminates of nanocellulose and poly(vinyl alcohol) was investigated by FTIR chemical imaging.
Journal ArticleDOI
High spatial resolution (1.1 μm and 20 nm) FTIR polarization contrast imaging reveals pre-rupture disorder in damaged tendon
Richard Wiens,Catherine R. Findlay,Samuel G. Baldwin,Laurent Kreplak,J. Michael Lee,Samuel P. Veres,Samuel P. Veres,Kathleen M. Gough +7 more
TL;DR: The first results of high-resolution FTIR polarization contrast imaging are presented, at 1.1 μm and 20 nm scales, on control and mechanically damaged tendon, to explore the changes induced in tendon after the application of damaging mechanical stress, and the consequences for the healing processes.
Journal ArticleDOI
FTIR studies of the similarities between pathology induced protein aggregation in vivo and chemically induced protein aggregation ex vivo
TL;DR: The new data presented highlights that the spectroscopic alterations to the amide I band often reported for amyloid-β plaques in Alzheimer’s disease, are spectroscopically very similar to spectroscopy alterations observed during ischemia induced neurodegeneration and ex vivo induced protein aggregation.
Journal ArticleDOI
Emerging Technologies and their Applications in Lipid Compartment Measurement
TL;DR: The union between new technologies and the growing NCD population is creating an exciting interface in advancing the understanding of chronic disease mechanisms, and newer approaches will give molecular structural and metabolic information beyond the laboratory in real-world settings.
Journal ArticleDOI
Nanoantenna-Enhanced Infrared Spectroscopic Chemical Imaging
Lucca Kühner,Mario Hentschel,Ute Zschieschang,Hagen Klauk,Jochen Vogt,Christian W. Huck,Harald Giessen,Frank Neubrech,Frank Neubrech +8 more
TL;DR: The results demonstrate the potential of nanoantenna-enhanced spectroscopic infrared chemical imaging for spatially resolved characterization of organic layers with thicknesses of several nanometers and provides chemical selectivity, which would not be available with plasmonic imaging that is based on refractive index sensing.
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