High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams
Michael J. Nasse,Michael J. Walsh,Eric C. Mattson,Ruben Reininger,Andre Kajdacsy-Balla,Virgilia Macias,Rohit Bhargava,Carol J. Hirschmugl +7 more
TLDR
This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.Abstract:
Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.read more
Citations
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Nano‐FTIR Investigation of the CM Chondrite Allan Hills 83100
Jordan M. Young,Timothy D. Glotch,Mehmet Yesiltas,Victoria E. Hamilton,L. B. Breitenfeld,Hans A. Bechtel,Stephanie N. Gilbert Corder,Ziheng Yao +7 more
TL;DR: In this article , the results of nano-FTIR spectroscopy and imaging measurements performed on the carbonaceous chondrite Allan Hills (ALH) 83100 (CM1/2) are reported.
Journal ArticleDOI
Quantitative infrared spectroscopy of environmentally sensitive and rough materials.
TL;DR: A miniaturized environmental chamber is designed and 3D-printed that can be directly inserted into the sample holder of a conventional integrating sphere to perform total transmission and reflection measurements in controlled environments and a calibration method was developed to exclude light scattering from rough surfaces of the sample and the distortion created by infrared windows.
Journal ArticleDOI
Digital Histopathology by Infrared Spectroscopic Imaging.
TL;DR: In this paper , an overview of data processing methods and application of machine learning is given, with an emphasis on the emerging use of deep learning, and a discussion on workflows in pathology is provided, with four categories proposed based on the complexity of methods and analytical performance needed.
Journal ArticleDOI
Characterisation of breast cancer molecular signature and treatment assessment with vibrational spectroscopy and chemometric approach
Magdalena Kolodziej,Ewa Kaznowska,Sylwia Paszek,Jozef Cebulski,Edyta Barnaś,Marian Cholewa,Jitraporn Vongsvivut,Izabela Zawlik +7 more
TL;DR: F Fourier Transform Infrared microspectroscopy combined with chemometrics and absorbance ratios investigation was employed to compare healthy controls with TNBC tissue before and after chemotherapy within the same patient, revealing discriminatory features reflecting a clinical response scheme.
ReportDOI
Differential Expression of Zinc Transporters in Prostate Epithelia of Racial Groups
TL;DR: The zinc transporters that may be disparately expressed in the prostate tissues of African American males as compared to European American males are studied to lead to identification of the potential molecular targets for preventive or therapeutic measures or nutritional, environmental or life style factors for their potential relationship to the incidence or progression of prostate cancer in various racial groups.
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