Journal ArticleDOI
Highly water-soluble, porous, and biocompatible boron nitrides for anticancer drug delivery.
Qunhong Weng,Binju Wang,Xuebin Wang,Nobutaka Hanagata,Xia Li,Dequan Liu,Xi Wang,Xiangfen Jiang,Yoshio Bando,Dmitri Golberg,Dmitri Golberg +10 more
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TLDR
An original and simple thermal substitution method is reported to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees.Abstract:
Developing materials for "Nano-vehicles" with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.read more
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Functionalized hexagonal boron nitride nanomaterials: emerging properties and applications.
TL;DR: An overview of the progress in functionalized hexagonal boron nitride (h-BN) nanomaterials can be found in this paper, where different functionalization methods, including physical and chemical routes, are comprehensively described toward fabrication of various BN derivatives, hetero- and porous structures, etc.
Journal ArticleDOI
Two-dimensional graphene analogues for biomedical applications.
TL;DR: The state-of-the-art progress of this dynamically developed material family of 2D-GAs with a particular focus on biomedical applications is summarized and some critical unresolved issues, possible challenges/obstacles are summarized.
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Boron nitride colloidal solutions, ultralight aerogels and freestanding membranes through one-step exfoliation and functionalization.
TL;DR: A simple, one-step mechano-chemical process to exfoliate and functionalize h-BN into highly water-dispersible, few-layer h-bn containing amino groups is presented.
Journal ArticleDOI
Two‐Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects
TL;DR: The unique characteristics that make 2D nanoparticles so valuable are described, as well as the biocompatibility framework that has been investigated so far, to capture the growing trend of 2D nanomaterials for biomedical applications and to identify promising new research directions.
Journal ArticleDOI
Scalable exfoliation process for highly soluble boron nitride nanoplatelets by hydroxide-assisted ball milling
TL;DR: Hydroxide-assisted ball milling process can provide simple and efficient approaches to scalable preparation of large-size and highly soluble BNNPs and is not only easily scalable but also applicable to other layered materials.
References
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A metal-free polymeric photocatalyst for hydrogen production from water under visible light
Xinchen Wang,Kazuhiko Maeda,Arne Thomas,Kazuhiro Takanabe,Gang Xin,Johan M. Carlsson,Kazunari Domen,Markus Antonietti +7 more
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Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.
Journal ArticleDOI
PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs
TL;DR: The results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.
Journal ArticleDOI
Nano-Graphene Oxide for Cellular Imaging and Drug Delivery.
Xiaoming Sun,Zhuang Liu,Kevin Welsher,Joshua T. Robinson,Andrew P. Goodwin,S. Zaric,Hongjie Dai +6 more
TL;DR: In this paper, the authors synthesize and explore the biological applications of nano-graphene oxide (NGO), i.e., single-layer graphene oxide sheets down to a few nanometers in lateral width.