Human Mineralocorticoid Receptor Genomic Structure and Identification of Expressed Isoforms
M C Zennaro,Maria-Cristina Keightley,Yuri Kotelevtsev,Gerard S. Conway,Florent Soubrier,Peter J. Fuller +5 more
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TLDR
The genomic structure of the human MR is determined and it is indicated that hMR expression is regulated by alternative promoters perhaps in a tissue- or developmental-specific manner.About:
This article is published in Journal of Biological Chemistry.The article was published on 1995-09-08 and is currently open access. It has received 142 citations till now. The article focuses on the topics: Mineralocorticoid receptor & Retinoic acid receptor.read more
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Brain corticosteroid receptor balance in health and disease.
TL;DR: The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.
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Stress, memory, and the hippocampus: can't live with it, can't live without it.
Sonia J. Lupien,Martin Lepage +1 more
TL;DR: The conclusion of this analysis will be that scientists should gain from extending the impact of stress hormones to other brain regions, since hormonal functions on the brain are best explained by their modulatory role on various brain structures, rather than by their unique impact on one particular brain region.
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Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation.
TL;DR: In the primate, neocortical and hypothalamic areas may be more important targets for GR-mediated effects of glucocorticoids than the hippocampus, and it is also possible that glucoc Corticoid effects are mediated through the MRs present in the hippocampal formation.
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Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I.
David S. Geller,Juan Rodriguez-Soriano,A Vallo Boado,S Schifter,M Bayer,Sandy Chang,Richard P. Lifton,Richard P. Lifton +7 more
TL;DR: It is demonstrated that heterozygous MLR mutations cause PHA1, underscore the important role of mineralocorticoid receptor function in regulation of salt and blood pressure homeostasis in humans and motivate further study of this gene for a potential role in blood pressure variation.
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The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology
Say Viengchareun,Damien Le Menuet,Laetitia Martinerie,Mathilde Munier,Laurent Pascual-Le Tallec,Marc Lombès +5 more
TL;DR: The structure, molecular mechanism of action and transcriptional regulation mediated by MR are described, emphasizing the most recent developments at the cellular and molecular level.
References
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Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
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PCR protocols : A guide to methods and applications
TL;DR: Basic Methodology: M.A. Innis and D.F. Frohman, RACE: Rapid Amplification of cDNA Ends, and RNA Processing: Apo-B.R. Kwok, Procedure to Minimuze PCR-Product Carry-Over.
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.