Journal ArticleDOI
Human skin: source of and target organ for angiotensin II.
U. Muscha Steckelings,Tanja Wollschläger,Jörg Peters,Beate M. Henz,Barbara Hermes,Metin Artuc +5 more
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TLDR
The findings suggest that the complete renin–angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.Abstract:
The present study examined the expression of angiotensin receptors in human skin, the potential synthesis of angiotensin II (Ang II) in this location and looked for a first insight into physiological functions. AT1 and AT2 receptors were found within the epidermis and in dermal vessel walls. The same expression pattern was found for angiotensinogen, renin and angiotensin-converting enzyme (ACE). All components could additionally be demonstrated at mRNA level in cultured primary keratinocytes, melanocytes, dermal fibroblasts and dermal microvascular endothelial cells, except for AT2 receptors in melanocytes. The ability of cutaneous cells to synthesize Ang II was proved by identifying the molecule in cultured keratinocytes. Furthermore, in artificially wounded keratinocyte monolayers, ACE-mRNA expression was rapidly increased, and enhanced ACE expression was still found in cutaneous human scars 3 months after wounding. These findings suggest that the complete renin-angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.read more
Citations
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Modulation of angiotensin II signaling in the prevention of fibrosis
TL;DR: Current knowledge on the role that angiotensin II plays in tissue fibrosis, as well as current and potential therapies targeting this system are reviewed.
Journal ArticleDOI
Matrix metalloproteinases: The sculptors of chronic cutaneous wounds.
TL;DR: The functions and skewed regulation of different MMPs during infection and chronic tissue repair are discussed and the potential of M MPs and their inhibitors as therapeutic agents in treating chronic wounds during distinct phases of the wound healing is pointed out.
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Mechanisms of disease: local renin-angiotensin-aldosterone systems and the pathogenesis and treatment of cardiovascular disease.
TL;DR: Evidence points to the conclusion that the RAASs are complexly regulated, multifunctional systems with important roles both within and outside the cardiovascular system.
Journal ArticleDOI
What are subcutaneous adipocytes really good for
J. Klein,P. A. Permana,M. Owecki,George N. Chaldakov,Markus Böhm,Gary J. Hausman,C. M. Lapière,Pepa Atanassova,J. Sowiński,M. Fasshauer,Dorothy B. Hausman,Erik Maquoi,Anton B. Tonchev,V. N. Peneva,K. P. Vlachanov,Marco Fiore,Luigi Aloe,Andrzej Slominski,C. L. Reardon,Terence J. Ryan,Caroline M. Pond +20 more
TL;DR: No basic scientist and no doctor with a serious interest in skin, and hardly anyone else in the life sciences, can afford to ignore the subcutaneous adipocyte – beyond its ample impact on beauty, benessence and body mass.
Journal ArticleDOI
Differential expression of angiotensin receptors in human cutaneous wound healing.
TL;DR: This data indicates that downregulation of AT2 receptors in human skin during tissue repair and remodelling in various noncutaneous human tissues is a major cause of apoptosis in animals.
References
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Journal ArticleDOI
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
TL;DR: The results show that the growth modulating actions of ANG II depend on the type of angiotensin receptor present on a given cell, and in coronary endothelial cells, the antiproliferative actions of the AT2-receptor offset the growth promoting effects mediated by the AT1- receptor.
Journal ArticleDOI
Identification of angiotensin II receptor subtypes
Andrew T. Chiu,William F. Herblin,Dale E. McCall,Robert John Ardecky,David J. Carini,John V. Duncia,Lori J. Pease,Pancras C. Wong,Ruth R. Wexler,Alexander L. Johnson,Pieter B.M.W.M. Timmermans +10 more
TL;DR: Two distinct subtypes of the angiotensin II receptor in the rat adrenal gland are demonstrated using radioligand binding and tissue section autoradiography and the discovery of two structurally dissimilar, nonpeptide compounds that show reciprocal selectivity for the two subtypes.
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Preliminary biochemical characterization of two angiotensin II receptor subtypes.
TL;DR: There is a good correlation between the affinities of the selected agonists and antagonists for the two subtypes in the various tissues tested which is a usual requirement for receptor classification.
Journal ArticleDOI
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
Masatoshi Nakajima,Howard G. Hutchinson,Masahiko Fujinaga,Wataru Hayashida,Ryuichi Morishita,Lunan Zhang,Masatsugu Horiuchi,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: Results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
Journal ArticleDOI
Circulating and tissue angiotensin systems.
TL;DR: In this review, a coherent model of the interaction between the circulating and tissue angiotensin systems is synthesized, which might assist in the interpretation of new developments in this area.