Journal ArticleDOI
Human skin: source of and target organ for angiotensin II.
U. Muscha Steckelings,Tanja Wollschläger,Jörg Peters,Beate M. Henz,Barbara Hermes,Metin Artuc +5 more
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TLDR
The findings suggest that the complete renin–angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.Abstract:
The present study examined the expression of angiotensin receptors in human skin, the potential synthesis of angiotensin II (Ang II) in this location and looked for a first insight into physiological functions. AT1 and AT2 receptors were found within the epidermis and in dermal vessel walls. The same expression pattern was found for angiotensinogen, renin and angiotensin-converting enzyme (ACE). All components could additionally be demonstrated at mRNA level in cultured primary keratinocytes, melanocytes, dermal fibroblasts and dermal microvascular endothelial cells, except for AT2 receptors in melanocytes. The ability of cutaneous cells to synthesize Ang II was proved by identifying the molecule in cultured keratinocytes. Furthermore, in artificially wounded keratinocyte monolayers, ACE-mRNA expression was rapidly increased, and enhanced ACE expression was still found in cutaneous human scars 3 months after wounding. These findings suggest that the complete renin-angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.read more
Citations
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Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids.
TL;DR: Inhibition of chymase might be an effective therapeutic approach to improve the clinical treatment of keloids and reduce the expression of signaling factors in keloid tissues.
Journal ArticleDOI
Can intradermal administration of angiotensin II influence human heat loss responses during whole body heat stress
Naoto Fujii,Robert D. Meade,Gabrielle Paull,Ryan McGinn,Imane Foudil-bey,Pegah Akbari,Glen P. Kenny +6 more
TL;DR: It is shown angiotensin II impairs cutaneous perfusion independent of oxidative stress, while it impairs sweating through increasing oxidative stress during exposure to an ambient heat stress before and following exercise.
Book
Neuroimmunology Of The Skin
TL;DR: Neuroimmunology of the skin :, Neuroimmunologists of theskin :, کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
Angiotensin II Type 1 Receptor Blockade Corrects Cutaneous Nitric Oxide Deficit in Postural Tachycardia Syndrome
TL;DR: The data suggest that the reduction in cutaneous NO-dependent vasodilation in low-flow POTS is corrected by AT(1)R blockade.
Journal ArticleDOI
Sweat gland regeneration: Current strategies and future opportunities
TL;DR: Recent progress in molecular biology, developmental pathways, and cellular evolution associated with SwG development and maturation is described and a summary of the current strategies used for cell-fate modulation, transmembrane drug delivery, and scaffold designassociated with SwGregeneration is described.
References
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Journal ArticleDOI
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
TL;DR: The results show that the growth modulating actions of ANG II depend on the type of angiotensin receptor present on a given cell, and in coronary endothelial cells, the antiproliferative actions of the AT2-receptor offset the growth promoting effects mediated by the AT1- receptor.
Journal ArticleDOI
Identification of angiotensin II receptor subtypes
Andrew T. Chiu,William F. Herblin,Dale E. McCall,Robert John Ardecky,David J. Carini,John V. Duncia,Lori J. Pease,Pancras C. Wong,Ruth R. Wexler,Alexander L. Johnson,Pieter B.M.W.M. Timmermans +10 more
TL;DR: Two distinct subtypes of the angiotensin II receptor in the rat adrenal gland are demonstrated using radioligand binding and tissue section autoradiography and the discovery of two structurally dissimilar, nonpeptide compounds that show reciprocal selectivity for the two subtypes.
Journal ArticleDOI
Preliminary biochemical characterization of two angiotensin II receptor subtypes.
TL;DR: There is a good correlation between the affinities of the selected agonists and antagonists for the two subtypes in the various tissues tested which is a usual requirement for receptor classification.
Journal ArticleDOI
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
Masatoshi Nakajima,Howard G. Hutchinson,Masahiko Fujinaga,Wataru Hayashida,Ryuichi Morishita,Lunan Zhang,Masatsugu Horiuchi,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: Results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
Journal ArticleDOI
Circulating and tissue angiotensin systems.
TL;DR: In this review, a coherent model of the interaction between the circulating and tissue angiotensin systems is synthesized, which might assist in the interpretation of new developments in this area.