Journal ArticleDOI
Human skin: source of and target organ for angiotensin II.
U. Muscha Steckelings,Tanja Wollschläger,Jörg Peters,Beate M. Henz,Barbara Hermes,Metin Artuc +5 more
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TLDR
The findings suggest that the complete renin–angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.Abstract:
The present study examined the expression of angiotensin receptors in human skin, the potential synthesis of angiotensin II (Ang II) in this location and looked for a first insight into physiological functions. AT1 and AT2 receptors were found within the epidermis and in dermal vessel walls. The same expression pattern was found for angiotensinogen, renin and angiotensin-converting enzyme (ACE). All components could additionally be demonstrated at mRNA level in cultured primary keratinocytes, melanocytes, dermal fibroblasts and dermal microvascular endothelial cells, except for AT2 receptors in melanocytes. The ability of cutaneous cells to synthesize Ang II was proved by identifying the molecule in cultured keratinocytes. Furthermore, in artificially wounded keratinocyte monolayers, ACE-mRNA expression was rapidly increased, and enhanced ACE expression was still found in cutaneous human scars 3 months after wounding. These findings suggest that the complete renin-angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.read more
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Distribution of cells expressing human renin-promoter activity in the brain of a transgenic mouse
Andrew M. Allen,Erin L. O'Callaghan,L. Hazelwood,Stéphane Germain,Hayo Castrop,Hayo Castrop,J. Schnermann,Jaspreet K. Bassi +7 more
TL;DR: The observations suggest that renin may have broader actions in the brain and may indicate a potential for interaction with the (pro)renin receptor or production of a ligand for non-AT(1)/AT(2) receptors.
Journal ArticleDOI
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Igor Maciel Souza Silva,Kasper Bostlund Assersen,Natalie Nanette Willadsen,Julie Jepsen,Metin Artuc,Ulrike Muscha Steckelings +5 more
TL;DR: The skin RAS is now in the critical phase of translation from preclinical evidence to clinical use, thus resulting in a multitude of preclinical studies pointing to the potential relevance of components of the RAS as drug targets in dermatological diseases.
Journal ArticleDOI
Expression of prothrombin, thrombin and its receptors in human scars.
TL;DR: The findings, showing a marked modulation of thrombin, PAR‐1 and TM even in older human scar tissue, suggest that the coagulation system is not only involved during clotting, but also during the inflammatory and tissue remodelling phases of wound healing.
Journal ArticleDOI
Valsartan solid lipid nanoparticles integrated hydrogel: A challenging repurposed use in the treatment of diabetic foot ulcer, in-vitro/in-vivo experimental study.
Noha S. El-Salamouni,Mennatallah A. Gowayed,Nevine L. Seiffein,Rehab Ahmed Abdel-Moneim,Maher A. Kamel,Gihan S Labib +5 more
TL;DR: Treatment with Val-SLN for 12 days revealed enhanced healing characteristics through cyclooxygenase-2 (COX-2), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), nitric oxide (NO), transforming growth factor-beta (TGF-β), matrix metalloproteinase (MMPs) and vascular endothelial growth factor (VEGF) pathways.
Journal ArticleDOI
Balance and circumstance: The renin angiotensin system in wound healing and fibrosis.
TL;DR: The tissue renin angiotensin system (tRAS) is a locally-acting master-modulator of tissue homeostasis and regeneration, and is emerging as an attractive target for therapies aiming to restore tissueHomeostasis in conditions associated with disturbed wound healing.
References
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Journal ArticleDOI
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
TL;DR: The results show that the growth modulating actions of ANG II depend on the type of angiotensin receptor present on a given cell, and in coronary endothelial cells, the antiproliferative actions of the AT2-receptor offset the growth promoting effects mediated by the AT1- receptor.
Journal ArticleDOI
Identification of angiotensin II receptor subtypes
Andrew T. Chiu,William F. Herblin,Dale E. McCall,Robert John Ardecky,David J. Carini,John V. Duncia,Lori J. Pease,Pancras C. Wong,Ruth R. Wexler,Alexander L. Johnson,Pieter B.M.W.M. Timmermans +10 more
TL;DR: Two distinct subtypes of the angiotensin II receptor in the rat adrenal gland are demonstrated using radioligand binding and tissue section autoradiography and the discovery of two structurally dissimilar, nonpeptide compounds that show reciprocal selectivity for the two subtypes.
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Preliminary biochemical characterization of two angiotensin II receptor subtypes.
TL;DR: There is a good correlation between the affinities of the selected agonists and antagonists for the two subtypes in the various tissues tested which is a usual requirement for receptor classification.
Journal ArticleDOI
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
Masatoshi Nakajima,Howard G. Hutchinson,Masahiko Fujinaga,Wataru Hayashida,Ryuichi Morishita,Lunan Zhang,Masatsugu Horiuchi,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: Results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
Journal ArticleDOI
Circulating and tissue angiotensin systems.
TL;DR: In this review, a coherent model of the interaction between the circulating and tissue angiotensin systems is synthesized, which might assist in the interpretation of new developments in this area.