Journal ArticleDOI
Human skin: source of and target organ for angiotensin II.
U. Muscha Steckelings,Tanja Wollschläger,Jörg Peters,Beate M. Henz,Barbara Hermes,Metin Artuc +5 more
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TLDR
The findings suggest that the complete renin–angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.Abstract:
The present study examined the expression of angiotensin receptors in human skin, the potential synthesis of angiotensin II (Ang II) in this location and looked for a first insight into physiological functions. AT1 and AT2 receptors were found within the epidermis and in dermal vessel walls. The same expression pattern was found for angiotensinogen, renin and angiotensin-converting enzyme (ACE). All components could additionally be demonstrated at mRNA level in cultured primary keratinocytes, melanocytes, dermal fibroblasts and dermal microvascular endothelial cells, except for AT2 receptors in melanocytes. The ability of cutaneous cells to synthesize Ang II was proved by identifying the molecule in cultured keratinocytes. Furthermore, in artificially wounded keratinocyte monolayers, ACE-mRNA expression was rapidly increased, and enhanced ACE expression was still found in cutaneous human scars 3 months after wounding. These findings suggest that the complete renin-angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.read more
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A novel role of angiotensin II in epidermal cell lineage determination: Angiotensin II promotes the differentiation of mesenchymal stem cells into keratinocytes through the p38 MAPK, JNK and JAK2 signalling pathways.
Xiao Jiang,Xiao Jiang,Fan Wu,Fan Wu,Yuan Xu,Yuan Xu,Jian-Xin Yan,Jian-Xin Yan,Yin-Di Wu,Yin-Di Wu,Sheng-Hong Li,Sheng-Hong Li,Xuan Liao,Xuan Liao,Jun-Xian Liang,Jun-Xian Liang,Ze-Hua Li,Ze-Hua Li,Hong-Wei Liu,Hong-Wei Liu +19 more
TL;DR: The potential impact of Ang II on MSC differentiation into keratinocytes is still unknown, but evidence suggests that angiotensin II plays a role in cutaneous wound healing.
Journal ArticleDOI
The up-regulation of angiotensin II receptor type 1 and connective tissue growth factor are involved in high-glucose-induced fibronectin production by cultured human dermal fibroblasts.
TL;DR: The up-regulation of angiotensin II receptor type 1 and the consequent increase of CTGF expression, independently of TGFbeta1, participate in high-glucose-induced fibronectin production in cultured human dermal fibroblasts.
Journal ArticleDOI
Cancer stem cell subpopulations in metastatic melanoma to the brain express components of the renin-angiotensin system
Agadha Wickremesekera,Helen D. Brasch,Valerie M. Lee,Paul F. Davis,Andrew Parker,Helge Koeck,Tinte Itinteang,Swee T. Tan +7 more
TL;DR: This study investigated the expression and localization of components of the RAS in relation to these CSCs in MM and demonstrated the presence of three CSC subpopulations within metastatic melanoma to the brain.
Journal ArticleDOI
EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice.
Adela García-Martín,Carmen Navarrete,Martín Garrido-Rodríguez,María E. Prados,Diego Caprioglio,Giovanni Appendino,Eduardo Muñoz +6 more
TL;DR: In this paper, the effect of EHP-101 on cardiac and other organ fibrosis in a mouse model induced by Angiotensin II was examined, and it was shown that EHP101 inhibited the expression of genes such as CDK1, TOP2A and MKi67 that are regulated to the E2 factor family of transcription factors.
Journal ArticleDOI
Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome
TL;DR: In this paper, Stewart et al. used local heating of the skin of the left calf to 42°C and laser-Doppler flowmetry to assess NO-dependent conductance [percent maximum cutaneous vascular conductance (%CVCmax)] in 12 low-flow postural tachycardia syndrome (POTS) patients aged 22.8-22.3 yr and 15 control subjects aged 22-0 1.5 yr.
References
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Journal ArticleDOI
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
TL;DR: The results show that the growth modulating actions of ANG II depend on the type of angiotensin receptor present on a given cell, and in coronary endothelial cells, the antiproliferative actions of the AT2-receptor offset the growth promoting effects mediated by the AT1- receptor.
Journal ArticleDOI
Identification of angiotensin II receptor subtypes
Andrew T. Chiu,William F. Herblin,Dale E. McCall,Robert John Ardecky,David J. Carini,John V. Duncia,Lori J. Pease,Pancras C. Wong,Ruth R. Wexler,Alexander L. Johnson,Pieter B.M.W.M. Timmermans +10 more
TL;DR: Two distinct subtypes of the angiotensin II receptor in the rat adrenal gland are demonstrated using radioligand binding and tissue section autoradiography and the discovery of two structurally dissimilar, nonpeptide compounds that show reciprocal selectivity for the two subtypes.
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Preliminary biochemical characterization of two angiotensin II receptor subtypes.
TL;DR: There is a good correlation between the affinities of the selected agonists and antagonists for the two subtypes in the various tissues tested which is a usual requirement for receptor classification.
Journal ArticleDOI
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
Masatoshi Nakajima,Howard G. Hutchinson,Masahiko Fujinaga,Wataru Hayashida,Ryuichi Morishita,Lunan Zhang,Masatsugu Horiuchi,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: Results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
Journal ArticleDOI
Circulating and tissue angiotensin systems.
TL;DR: In this review, a coherent model of the interaction between the circulating and tissue angiotensin systems is synthesized, which might assist in the interpretation of new developments in this area.