Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging
TLDR
Activatable probes are developed, designed to be fluorescently quenched at a quiescent stage but activatable when encountering a specific trigger, which leads to a structural or conformational change and restores fluorescence activities.Abstract:
Near-infrared fluorescence (NIRF) imaging is emerging as an important tool in preclinical studies.[1–5] As the technology is being established and implemented worldwide, a wave of effort has been spurred to develop novel imaging probes that can accurately recognize and report diseases, such as cancer.[3,6] One common drawback of NIRF imaging, however, is its high background and as a consequence of that, low specificity.[7,8] To address this issue, we and others have developed activatable probes with various approaches. Such probes, constructed by bringing into proximity an energy donor and receptor, are designed to be fluorescently quenched at a quiescent stage but activatable when encountering a specific trigger, which leads to a structural or conformational change and restores fluorescence activities.[7–9] This technique allows the signals to be only amplified at diseased areas upon a designated environment change, a feature which can greatly improve the signal-to-background ratio.read more
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Magnetoferritin nanoparticles for targeting and visualizing tumour tissues
Kelong Fan,Changqian Cao,Yongxin Pan,Di Lu,Dongling Yang,Jing Feng,Lina Song,Minmin Liang,Xiyun Yan +8 more
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RGD-modified apoferritin nanoparticles for efficient drug delivery to tumors
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Graphene-based nanomaterials for bioimaging ☆
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Biodegradable and Renal Clearable Inorganic Nanoparticles.
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Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy
TL;DR: This work fabricates a dual-stimuli-responsive and reversibly activatable nanoprobe from asymmetric cyanine and glycosyl-functionalized gold nanorods with matrix metalloproteinases-specific peptide as a linker to achieve MMPs/pH synergistic and pH reversible activation.
References
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