Journal ArticleDOI
Hypoxia-dependent accumulation of hypoxia-inducible factor-1 alpha induces transient cell cycle arrest in porcine trophectoderm cells.
TLDR
Mechanisms underlying the adaptation of pig embryos to oxygen deficiency in the maternal-conceptus microenvironment are determined and understating of cellular adaptation of developing pre-implantation porcine conceptuses to hypoxic stress is advanced.About:
This article is published in Theriogenology.The article was published on 2018-07-15. It has received 8 citations till now. The article focuses on the topics: Hypoxia (medical) & Cell cycle.read more
Citations
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Journal ArticleDOI
Effects of curcumin on hypoxia-inducible factor as a new therapeutic target.
TL;DR: The knowledge about the pharmacological effects of curcumin on HIF‐1 and the related molecular mechanisms that may be effective candidates for the development of multi‐targeted therapy for several human diseases are summarized.
Journal ArticleDOI
The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro
TL;DR: It is found that the PDT activity of 1-P can degrade SIRT1, and activate the Fas signal pathway to inhibit the growth of liver cancer cells, which suggesting this kind of corrole is a powerful and promising antitumor PS for PDT.
Journal ArticleDOI
Aristolochic acid induces renal fibrosis by arresting proximal tubular cells in G2/M phase mediated by HIF-1α.
Hao Zhao,Na Jiang,Yachun Han,Ming Yang,Peng Gao,Xiaofen Xiong,Shan Xiong,Lingfeng Zeng,Ying Xiao,Ling Wei,Li Li,Chenrui Li,Jinfei Yang,Chengyuan Tang,Li Xiao,Fuyou Liu,Yu Liu,Lin Sun +17 more
TL;DR: Data indicate that HIF‐1α plays a key role in renal fibrosis in AAN by inducing PTCs G2/M arrest modulated through p21, and may serve as a potential therapeutic target for AAN.
Journal ArticleDOI
The insights into molecular pathways of hypoxia‐inducible factor in the brain
TL;DR: The knowledge of HIF pathways might be helpful in devising HIF‐mimetics and modulating drugs, acting on the molecular level to improve clinical outcomes, as exemplified here by clinical and experimental data of selected brain diseases, occasionally corroborated by the data from disorders of other organs.
Journal ArticleDOI
Three dimensionally printed nitrocellulose-based microfluidic platform for investigating the effect of oxygen gradient on cells
Ping Liu,Ping Liu,Longwen Fu,Zhihua Song,Mingsan Man,Huamao Yuan,Xiaoli Zheng,Qi Kang,Dazhong Shen,Jinming Song,Bowei Li,Lingxin Chen +11 more
TL;DR: In this article, a 3D printed microfluidic chip with 3D printing technology was used to study the effect of oxygen gradient on cells, which can provide a variety of analysis methods for cells, including flow cytometry, western blot and RT-PCR.
References
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Journal ArticleDOI
Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
Panu Jaakkola,David R. Mole,Ya-Min Tian,Michael I. Wilson,Janine Gielbert,Simon J. Gaskell,Alex von Kriegsheim,Holger F. Hebestreit,Mridul Mukherji,Christopher J. Schofield,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe +12 more
TL;DR: It is shown that the interaction between human pVHL and a specific domain of the HIF-1α subunit is regulated through hydroxylation of a proline residue by an enzyme the authors have termed Hif-α prolyl-hydroxylase (HIF-PH).
Journal ArticleDOI
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Gregg L. Semenza,Guang L. Wang +1 more
TL;DR: A functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by Hypoxia via de novo protein synthesis.
Journal ArticleDOI
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Peter Carmeliet,Yuval Dor,Jean-Marc Herbert,Dai Fukumura,Koen Brusselmans,Mieke Dewerchin,Michal Neeman,Françoise Bono,Rinat Abramovitch,Patrick H. Maxwell,Cameron J. Koch,Peter J. Ratcliffe,Lieve Moons,Rakesh K. Jain,Desire Collen,Eli Keshert +15 more
TL;DR: It is shown that hypoxia and hypoglycaemia reduce proliferation and increase apoptosis in wild-type (Hif-1α+/+) embryonic stem (ES) cells, but not in ES cells with inactivated HIF-1 α genes (HIF- 1α−/−), suggesting that there are at least two different adaptive responses to being deprived of oxygen and nutrients.
Journal ArticleDOI
Purification and Characterization of Hypoxia-inducible Factor 1
Guang L. Wang,Gregg L. Semenza +1 more
TL;DR: The biochemical purification of HIF-1 from Epo-producing Hep3B cells and non-Epo-producing HeLa S3 cells concludes that in both cobalt chloride-treated HeLa cells and hypoxic Hep3 B cells HIF -1 is composed of two different subunits: 120-kDa Hif-1α and 91-94-k da HIF,1β.
Journal ArticleDOI
Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits
B. Fischer,B. D. Bavister +1 more
TL;DR: This study indicates that embryos develop in vivo under low oxygen concentrations, especially during the peri-implantation period, and has implications for investigations of embryo metabolism and for improving embryo development in vitro.
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