IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer s disease mouse model
Niklas Lonnemann,Shirin Hosseini,Melanie Ohm,Karsten Hiller,Charles A. Dinarello,Martin Korte +5 more
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In this article, the effects of IL-37 on neuronal architecture and function, microglia phenotype, cytokine production and behavior after inflammatory challenge by intraperitoneal LPS-injection.Abstract:
The anti-inflammatory cytokine interleukin-37 (IL-37) is a member of the IL-1 family but not expressed in mice. We used a human IL 37 (hIL-37tg) expressing mouse, which has been subjected to various models of local and systemic inflammation as well as immunological challenges. Those studies demonstrate an immune-modulatory role of IL-37 which can be characterized as an important suppressor of innate immunity. We investigated the functions of IL-37 in the CNS and explored the effects of IL-37 on neuronal architecture and function, microglia phenotype, cytokine production and behavior after inflammatory challenge by intraperitoneal LPS-injection. Reduced spine density, activated microglia phenotype and impaired long-term potentiation (LTP) were observed in wild-type mice after LPS injection, whereas hIL-37tg mice showed no impairment. In addition, we crossed the hIL-37tg mouse with an animal model of Alzheimer9s disease (APP/PS1) to investigate the anti-inflammatory properties of IL-37 under chronic neuroinflammatory conditions. Our results show that IL-37 is able to limit inflammation in the brain after acute inflammatory events and prevent the loss of cognitive abilities in a mouse model of AD.read more
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Activation of Mast Cells by Neuropeptides: The Role of Pro-Inflammatory and Anti-Inflammatory Cytokines
Dorina Lauritano,Filiberto Mastrangelo,Cristian D'Ovidio,Gianpaolo Ronconi,Alessandro Caraffa,C E Gallenga,I Frydas,S. K. Kritas,Matteo Trimarchi,Francesco Carinci,Pio Conti +10 more
TL;DR: In this article , the authors explored the current understanding of MC activation by neuropeptide substance P (SP), corticotropin-releasing hormone (CRH), and neurotensin, suggesting a therapeutic effect of the anti-inflammatory cytokines IL-37 and IL-38.
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How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes.
Shirin Hosseini,Martin Korte +1 more
TL;DR: In this article , the authors summarize the recent contributions of microglia and astrocytes to the neurological impairments caused by viral infections, and show that the ability to enter the central nervous system and cause neuronal infection does not appear to determine whether a viral strain causes neurological complications.
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Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress
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A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells
TL;DR: In this paper , a co-culture system consisting of bEnd.3 cells and LPS-activated Raw 264.7 cells was established to study effects of macrophage-derived inflammatory mediators associated with systemic inflammation on brain endothelial cells.
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