Imaging challenges in biomaterials and tissue engineering.
Alyssa A. Appel,Mark A. Anastasio,Jeffery C. Larson,Jeffery C. Larson,Eric M. Brey,Eric M. Brey +5 more
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TLDR
This review focuses on evaluating the application of available imaging modalities for assessment of biomaterials and tissue in TERM applications and a discussion of limitations of these techniques and identification of areas for further development.About:
This article is published in Biomaterials.The article was published on 2013-09-01 and is currently open access. It has received 235 citations till now.read more
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Regenerative medicine: Current therapies and future directions.
Angelo S. Mao,David J. Mooney +1 more
TL;DR: Developments in fabricating sophisticated grafts and tissue mimics and technologies for integrating grafts with host vasculature will be discussed, and directions for current and future regenerative medicine therapies are proposed.
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Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy.
Jibin Song,Xiangyu Yang,Orit Jacobson,Lisen Lin,Peng Huang,Gang Niu,Qingjie Ma,Xiaoyuan Chen +7 more
TL;DR: The rGO-AuNRVe-DOX capable of sequential DOX release by laser light and acid environment may have the potential for clinical translation to treat cancer patients with tumors accessible by light.
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Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine
Kevin Dzobo,Kevin Dzobo,Nicholas Ekow Thomford,Dimakatso Alice Senthebane,Dimakatso Alice Senthebane,Hendrina Shipanga,Hendrina Shipanga,Arielle Rowe,Collet Dandara,Michael Pillay,Keolebogile Shirley Motaung +10 more
TL;DR: Several challenges must be overcome in the application of 3D bioprinting before this disruptive technology is widely used to create organotypic constructs for regenerative medicine.
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Engineering Cellular Microenvironments with Photo- and Enzymatically Responsive Hydrogels: Toward Biomimetic 3D Cell Culture Models.
TL;DR: Progress is described in designing stimuli-responsive, optically transparent hydrogels that can be used as biomimetic extracellular matrices (ECMs) to study cell differentiation and migration in the context of modeling the nervous system and cancer.
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Imaging strategies for tissue engineering applications.
TL;DR: Commonly used biomedical imaging modalities, including X-ray and computed tomography, positron emission tomography and single photon emission computed tomographic, magnetic resonance imaging, ultrasound imaging, optical imaging, and emerging techniques and multimodal imaging, will be discussed, focusing on the latest trends of their applications in recent tissue engineering studies.
References
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Analysis of progenitor cell-scaffold combinations by in vivo non-invasive photonic imaging.
Irene Román,Marta Vilalta,Julio Rodriguez,Annette M. Matthies,Samer Srouji,Erella Livne,Jeffrey A. Hubbell,Nuria Rubio,Jerónimo Blanco +8 more
TL;DR: The implementation of a procedure based on the use of the luciferase gene as a cell proliferation tracer to monitor, by in vivo non-invasive imaging, the performance of stem cell-biomaterial combinations used for tissue regeneration is reported.
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An overview of methods for the in vivo evaluation of tissue-engineered skin constructs.
Gerwen Lammers,Pauline D. H. M. Verhaegen,Magda M. W. Ulrich,Joost Schalkwijk,Esther Middelkoop,Daniela Weiland,Suzan T.M. Nillesen,Toin H. van Kuppevelt,Willeke F. Daamen +8 more
TL;DR: The aim of this review is to provide researchers in the field of tissue engineering an overview of the methods that are currently used to clinically evaluate skin wound healing, and methods that is used to evaluate tissue-engineered constructs in animal models.
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X-Ray Synchrotron Radiation Pseudo-Holotomography as a New Imaging Technique to Investigate Angio- and Microvasculogenesis with No Usage of Contrast Agents
Vladimir S. Komlev,Maddalena Mastrogiacomo,Françoise Peyrin,Ranieri Cancedda,Franco Rustichelli +4 more
TL;DR: X-ray synchrotron radiation pseudo-holotomography is used to visualize, at 3D level, microvascular networks for the first time with no need for contrast agents, and to extract quantitative structural data in a bone-engineered construct implanted for 24 weeks in a mouse.
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X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods
Yanyin Yang,Shauna M. Dorsey,Matthew L. Becker,Sheng Lin-Gibson,Gary E. Schumacher,Glenn M. Flaim,Joachim Kohn,Carl G. Simon +7 more
TL;DR: Only two scaffold libraries were required to determine these minimum pI(2)DTEc percentages required for X-ray imaging, which demonstrates the efficiency of this new combinatorial approach for optimizing scaffold formulations.
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Quantitative, Structural and Image-based Mechanical Analysis of Nonunion Fracture Repaired by Genetically Engineered Mesenchymal Stem Cells
Ilan Kallai,G. Harry van Lenthe,G. Harry van Lenthe,Davide Ruffoni,Yoram Zilberman,Ralph Müller,Gadi Pelled,Gadi Pelled,Dan Gazit,Dan Gazit +9 more
TL;DR: Although MSCs induce bone formation, which exceeds the fracture site, significant remodeling of the repair callus occurs over time, which could indicate the clinical benefit of future MSC application in nonunion fracture repair.