Journal ArticleDOI
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.
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TLDR
Cationic host defense peptides were originally studied for their direct antimicrobial activities but have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models.Abstract:
Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use.read more
Citations
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Antimicrobial Peptides: Challenging Journey to the Pharmaceutical, Biomedical, and Cosmeceutical Use
TL;DR: Antimicrobial peptides (AMPs) are short proteins in various life forms as mentioned in this paper , which may become a promising substitute or adjuvant in pharmaceutical, biomedical, and cosmeceutical uses.
Bioinformatics: Novel Insights from Genomic Information.
TL;DR: How a variety of computational tools developed enable novel hypotheses about mechanisms associated with diseases and the mechanisms of action of immunomodulatory and other interventions, the definition of mechanism-based biomarkers/diagnostics, and prospective new interventions based on drug repurposing are illustrated.
Journal ArticleDOI
Antimicrobial Peptides in Cervicovaginal Lavage of Women Married to HIV Sero-Reactive Men are not Associated with Resistance to HIV butModulate Mucosal Pro-Inflammatory Response
TL;DR: Antimicrobial peptide expression in the CVLs showed no significant association with resistance to HIV infection and hBD3 inhibited the pro-inflammatory immune responses induced by CVL, indicating its novel therapeutic potential in HIV infection.
A Study on Transcriptomic Profiling of Differentially Expressed Genes Relevant to Innate and Adaptive Immune Pathways in Transgenic Rainbow Trout (Oncorhynchus mykiss) Harboring Cecropin P1 Transgene
TL;DR: The hypothesis that cecropin P1 transgene product may not only directly eliminate microbial pathogens, but also indirectly exert immunomodulatory activity in the transgenic hosts to elevate their disease resistance is hypothesized.
Journal ArticleDOI
Dimerization of cell-penetrating buforin II enhances antimicrobial properties
Hyunhee Lee,Sung-Tae Yang +1 more
TL;DR: In this article, Lys-linked homodimers of membrane-permeabilizing magainin II and cell-penetrating buforin II were used to study the effect of AMP dimerization on the properties of pathogenic bacteria.
References
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Journal ArticleDOI
Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
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Designing antimicrobial peptides: form follows function
TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
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Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells
De Yang,Qian Chen,Albert P. Schmidt,G. Mark Anderson,Ji Ming Wang,Joseph Wooters,Joost J. Oppenheim,Oleg Chertov +7 more
TL;DR: The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.
Journal ArticleDOI
Innate antimicrobial peptide protects the skin from invasive bacterial infection.
Victor Nizet,Takaaki Ohtake,Takaaki Ohtake,Xavier Lauth,Xavier Lauth,Janet M. Trowbridge,Janet M. Trowbridge,Jennifer A. Rudisill,Jennifer A. Rudisill,Robert A. Dorschner,Robert A. Dorschner,Vasumati K. Pestonjamasp,Vasumati K. Pestonjamasp,Joseph Piraino,Kenneth H. Huttner,Richard L. Gallo,Richard L. Gallo +16 more
TL;DR: It is shown that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS).