Journal ArticleDOI
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.
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TLDR
Cationic host defense peptides were originally studied for their direct antimicrobial activities but have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models.Abstract:
Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use.read more
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Poly-Arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-Induced Stroke in the Sprague Dawley Rat.
Bruno P. Meloni,Bruno P. Meloni,Samantha M South,Daphne A. Gill,Amber L. Marriott,Robert A. Déziel,Angela Jacques,David Blacker,David Blacker,Neville W. Knuckey,Neville W. Knuckey +10 more
TL;DR: R18 and R18D are effective in improving long-term functional outcomes after stroke, and suggests that R18 may be more effective than NA-1, which is currently in phase 3 clinical stroke trials.
Journal ArticleDOI
Mechanistic insights and therapeutic opportunities of antimicrobial chemokines.
TL;DR: A developing framework for leveraging chemokine-mediated bactericidal and immunomodulatory effects to advance pioneering therapeutic approaches for treating bacterial infections, including those caused by multidrug-resistant pathogens is highlighted.
Journal ArticleDOI
Identification of the Crucial Residues in the Early Insertion of Pardaxin into Different Phospholipid Bilayers
Majid Jafari,Faramarz Mehrnejad,Raheleh Aghdami,Nader Chaparzadeh,Zahra Razaghi Moghadam Kashani,Farahnoosh Doustdar +5 more
TL;DR: The results revealed that the N-terminal domain of the peptide, particularly the Phe 2 and (/or) Phe 3 residues, has a crucial role in early insertion, independent of the type of lipid bilayers.
Journal ArticleDOI
Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice.
Elisa C. Martinez,Elisa C. Martinez,Ravendra Garg,Pratima Shrivastava,Susantha Gomis,Sylvia van Drunen Littel-van den Hurk,Sylvia van Drunen Littel-van den Hurk +6 more
TL;DR: The capacity of this formulation to prevent PVM and possibly other viral respiratory infections is demonstrated and modulated the delayed exacerbated nature of PVM disease without any short-term side effects.
Journal ArticleDOI
Delivery by Dendritic Mesoporous Silica Nanoparticles Enhances the Antimicrobial Activity of a Napsin-Derived Peptide Against Intracellular Mycobacterium tuberculosis.
Bastian Beitzinger,Fabian Gerbl,Thomas Vomhof,Roman Schmid,Reiner Noschka,Armando Rodríguez,Sebastian Wiese,Gilbert Weidinger,Ludger Ständker,Paul Walther,Jens Michaelis,Mika Lindén,Steffen Stenger +12 more
TL;DR: In this article, a new antimicrobial peptide named NapFab was discovered by isolation from bronchoalveolar lavage and peptide optimization, and the peptide was loaded onto dendritic mesoporous silica nanoparticles (DMSN) as a carrier system, cellular uptake and consequently antimycobacterial activity against intracellular Mtb was significantly enhanced.
References
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Journal ArticleDOI
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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
Designing antimicrobial peptides: form follows function
TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
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Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells
De Yang,Qian Chen,Albert P. Schmidt,G. Mark Anderson,Ji Ming Wang,Joseph Wooters,Joost J. Oppenheim,Oleg Chertov +7 more
TL;DR: The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.
Journal ArticleDOI
Innate antimicrobial peptide protects the skin from invasive bacterial infection.
Victor Nizet,Takaaki Ohtake,Takaaki Ohtake,Xavier Lauth,Xavier Lauth,Janet M. Trowbridge,Janet M. Trowbridge,Jennifer A. Rudisill,Jennifer A. Rudisill,Robert A. Dorschner,Robert A. Dorschner,Vasumati K. Pestonjamasp,Vasumati K. Pestonjamasp,Joseph Piraino,Kenneth H. Huttner,Richard L. Gallo,Richard L. Gallo +16 more
TL;DR: It is shown that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS).