Journal ArticleDOI
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.
Reads0
Chats0
TLDR
Cationic host defense peptides were originally studied for their direct antimicrobial activities but have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models.Abstract:
Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use.read more
Citations
More filters
Journal ArticleDOI
High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine.
TL;DR: Cathelicidin-WA effectively attenuated inflammation, enhanced intestinal barrier function, and improved microbiota composition in the intestines of weaned piglets.
Journal ArticleDOI
Nuclease Activity Gives an Edge to Host-Defense Peptide Piscidin 3 over Piscidin 1, Rendering it more Effective against Persisters and Biofilms
M. Daben J. Libardo,Ali Adem Bahar,Buyong Ma,Riqiang Fu,Laura E. McCormick,Jun Zhao,Scott A. McCallum,Ruth Nussinov,Ruth Nussinov,Dacheng Ren,Alfredo M. Angeles-Boza,Myriam Cotten +11 more
TL;DR: It is demonstrated that the N‐termini of both peptides coordinate Cu2+ and p3‐Cu cleaves isolated DNA at a rate on par with free Cu2 + but significantly faster than p1‐Cu, which is commensurate with stronger peptide‐induced DNA damage.
Journal ArticleDOI
Mechanism of antifungal activity of antimicrobial peptide APP, a cell-penetrating peptide derivative, against Candida albicans : intracellular DNA binding and cell cycle arrest
TL;DR: Results indicated that APP kills C. albicans for efficient cell-penetrating efficiency, strong DNA-binding affinity and significant physiological changes inducing S-phase arrest in intracellular environment.
Journal ArticleDOI
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities
Osmar N. Silva,Osmar N. Silva,C. de la Fuente-Núñez,Evan F. Haney,Isabel C. M. Fensterseifer,Isabel C. M. Fensterseifer,Suzana M. Ribeiro,William F. Porto,Paul D. Brown,Celio Faria-Junior,Taia Maria Berto Rezende,Susana Elisa Moreno,Timothy K. Lu,Robert E. W. Hancock,Octavio L. Franco +14 more
TL;DR: In this article, a synthetic peptide called clavanin-MO, derived from a marine tunicate antimicrobial peptide, which exhibits potent antimicrobial and immunomodulatory properties both in vitro and in vivo, is presented.
Journal ArticleDOI
Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7
Gimano D. Amatngalim,Yolanda van Wijck,Yvonne de Mooij-Eijk,Renate M. Verhoosel,Jürgen Harder,Annemarie N. Lekkerkerker,Richard A.J. Janssen,Pieter S. Hiemstra +7 more
TL;DR: It is reported that basal cells are the principal cell type producing RNase 7 in cultured primary bronchial epithelial cells (PBEC) and a phenotype-specific innate immune activity of airway epithelial basal cells is demonstrated that is induced by cigarette smoke exposure.
References
More filters
Journal ArticleDOI
Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
Designing antimicrobial peptides: form follows function
TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
Journal ArticleDOI
Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells
De Yang,Qian Chen,Albert P. Schmidt,G. Mark Anderson,Ji Ming Wang,Joseph Wooters,Joost J. Oppenheim,Oleg Chertov +7 more
TL;DR: The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.
Journal ArticleDOI
Innate antimicrobial peptide protects the skin from invasive bacterial infection.
Victor Nizet,Takaaki Ohtake,Takaaki Ohtake,Xavier Lauth,Xavier Lauth,Janet M. Trowbridge,Janet M. Trowbridge,Jennifer A. Rudisill,Jennifer A. Rudisill,Robert A. Dorschner,Robert A. Dorschner,Vasumati K. Pestonjamasp,Vasumati K. Pestonjamasp,Joseph Piraino,Kenneth H. Huttner,Richard L. Gallo,Richard L. Gallo +16 more
TL;DR: It is shown that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS).