Journal ArticleDOI
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TLDR
Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.Abstract:
The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli. VR1-/- mice showed normal responses to noxious mechanical stimuli but exhibited no vanilloid-evoked pain behavior, were impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.read more
Citations
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Neuronal cell lines as model dorsal root ganglion neurons A transcriptomic comparison
TL;DR: Insight is provided into the receptor repertoire expressed in common dorsal root ganglion neuron-derived cell lines compared with whole murine dorsalRoot ganglions, and the limits and potentials of these cell lines as tools for neuropharmacological exploration are illustrated.
OtherDOI
Fever, Immunity, and Molecular Adaptations
TL;DR: The phylogenetically conserved mechanisms that regulate fever are reviewed and the effects that febrile-range temperatures have on multiple biological processes involved in host defense and cell death and survival are discussed, including the HSR and its implications for patients with severe sepsis, trauma, and other acute systemic inflammatory states.
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Modulation of neuroinflammation: Role and therapeutic potential of TRPV1 in the neuro-immune axis
TL;DR: The literature supports the hypothesis that TRPV1 may represent potential therapeutic targets in the neuro-immune axis and evidenced that inflammation modulates the expression and activity of TRpV1 in the central nervous system (CNS) and TRPv1 exerts reciprocal actions over neuroinflammatory processes.
Journal ArticleDOI
Anandamide and the question of its functional role for activation of capsaicin receptors.
Journal ArticleDOI
Disorders of membrane channels or channelopathies.
TL;DR: The complex picture of the genetic and molecular structures of channels will require frequent updates and more than one gene may regulate a function in a channel, thus different genetic mutations may manifest with the same disorder.
References
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Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Journal ArticleDOI
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal ArticleDOI
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Peter M. Zygmunt,Jesper Petersson,David Andersson,Huai-hu Chuang,Morten Sørgård,Vincenzo Di Marzo,David Julius,Edward D. Högestätt +7 more
TL;DR: It is shown that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP), which indicates that the vanilloid receptor may be another molecular target for endogenousAnandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
Journal Article
Vanilloid (Capsaicin) Receptors and Mechanisms
Arpad Szallasi,Peter M. Blumberg +1 more
TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.