Journal ArticleDOI
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TLDR
Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.Abstract:
The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli. VR1-/- mice showed normal responses to noxious mechanical stimuli but exhibited no vanilloid-evoked pain behavior, were impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.read more
Citations
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Journal ArticleDOI
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
TL;DR: It is argued that TRPV1 antagonists alone or in conjunction with other analgesics will improve the quality of life of people with migraine, chronic intractable pain secondary to cancer, AIDS or diabetes, and emerging data indicate that TRPs could be useful in treating disorders other than pain, such as urinary urge incontinence, chronic cough and irritable bowel syndrome.
Journal ArticleDOI
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Jon Kar Zubieta,Yolanda R. Smith,Joshua A. Bueller,Yanjun Xu,Michael R. Kilbourn,Douglas M. Jewett,Charles R. Meyer,Robert A. Koeppe,Christian S. Stohler +8 more
TL;DR: Sustained pain induced the regional release of endogenous opioids interacting with μ-opioid receptors in a number of cortical and subcortical brain regions, resulting in reductions in the sensory and affective ratings of the pain experience.
Journal ArticleDOI
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Graham D Smith,Martin J. Gunthorpe,Rosemary E. Kelsell,Philip David Hayes,P. Reilly,Paul Facer,James Wright,Jeffrey C. Jerman,Jean-Philippe Walhin,Lezanne Ooi,Julie Egerton,K. J. Charles,Darren Smart,Andrew D. Randall,Praveen Anand,John B. Davis +15 more
TL;DR: A member of the vanilloid receptor/TRP gene family, vanilloids receptor-like protein 3 (VRL3, also known as TRPV3), is identified, which is heat-sensitive but capsaicin-insensitive, suggesting the existence of thermosensitive receptors distinct from VR1.
Journal ArticleDOI
ThermoTRP channels and beyond: mechanisms of temperature sensation
TL;DR: The thermoTRPs, a subset of transient receptor potential ion channels are activated by distinct physiological temperatures, and are involved in converting thermal information into chemical and electrical signals within the sensory nervous system.
Journal ArticleDOI
painless, a Drosophila gene essential for nociception
TL;DR: In response to the touch of a probe heated above 38 degrees C, Drosophila larvae produce a stereotypical rolling behavior, unlike the response to an unheated probe, and a genetic screen for mutants defective in this noxious heat response was identified, identifying the painless gene.
References
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Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Journal ArticleDOI
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal ArticleDOI
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Peter M. Zygmunt,Jesper Petersson,David Andersson,Huai-hu Chuang,Morten Sørgård,Vincenzo Di Marzo,David Julius,Edward D. Högestätt +7 more
TL;DR: It is shown that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP), which indicates that the vanilloid receptor may be another molecular target for endogenousAnandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
Journal Article
Vanilloid (Capsaicin) Receptors and Mechanisms
Arpad Szallasi,Peter M. Blumberg +1 more
TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.