Journal ArticleDOI
In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices.
TLDR
In this work, the nanocomposite beads prepared under optimum condition could prolong the release of DS for 8h more compared with the pristine SA hydrogel beads and the entrapment efficiency and release rate of DS was improved, and the burst release ofDS was overcome.About:
This article is published in Acta Biomaterialia.The article was published on 2010-02-01. It has received 201 citations till now. The article focuses on the topics: Controlled release & Fluorescence spectrometry.read more
Citations
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Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model.
TL;DR: This study is the first to show that exosomes derived from PRP (PRP-Exos) may exert the function of PRP, and provides evidence of the probable molecular mechanisms underlying the PRP effect on healing of chronic ulcers and describes a promising resource of growth factors from exosome without species restriction.
Journal ArticleDOI
Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers
TL;DR: The loaded AMX within the n-HA/PLGA hybrid nanofibers shows a sustained release profile and a non-compromised activity to inhibit the growth of a model bacterium, Staphylococcus aureus.
Journal ArticleDOI
Applications of nanocomposite hydrogels for biomedical engineering and environmental protection
Gaurav Sharma,Bharti Thakur,Mu. Naushad,Amit Kumar,Florian J. Stadler,Sulaiman M. Alfadul,Genene Tessema Mola +6 more
TL;DR: Nanocomposite hydrogels have special characteristics such as high swelling rate, selectivity and stimuli-sensitive nature and are therefore good bio-absorbent materials for environmental detoxification and biomedical engineering.
Journal ArticleDOI
Alginate drug delivery systems: application in context of pharmaceutical and biomedical research
TL;DR: Worldwide researchers are exploring possible applications of alginates as coating material, preparation of controlled-release drug delivery systems such as microspheres, beads, pellets, gels, fibers, membranes, etc.
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One-pot synthesis of antibacterial chitosan/silver bio-nanocomposite hydrogel beads as drug delivery systems.
TL;DR: In vitro drug release test was carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system and they demonstrated good antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria.
References
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Journal ArticleDOI
Preparation and mechanical properties of chitosan/carbon nanotubes composites.
TL;DR: The mechanical properties, including the tensile modulus and strength, of the nanocomposites are greatly improved by about 93% and 99%, respectively, with incorporation of only 0.8 wt % of MWNTs into the chitosan matrix.
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A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system
TL;DR: Results showed that HTCC-PEG-GP formulation can be used as nasal drug delivery system to improve the absorption of hydrophilic macromolecular drugs.
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Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2.
TL;DR: A novel tissue engineering scaffold with the capability of controlled releasing BMP-2-derived synthetic peptide is developed and offers a new delivery method of growth factors and a novel scaffold design for bone regeneration.
Journal ArticleDOI
Kinetics of hydroxyapatite precipitation at pH 10 to 11.
TL;DR: The mechanism and kinetics of hydroxyapatite precipitation from aqueous solution at the conditions of pH 10-11 and at calcium ion concentrations of more than 0.5 mol/l were investigated and showed that the reaction undergoes the following process: transferring from octacalcium phosphate to amorphous calcium phosphate rapidly, and then from ACP to calcium-deficient hydroxyAPatite (DAP) and HAP.
Journal ArticleDOI
Alginate/chitosan particulate systems for sodium diclofenac release
M.L. González-Rodríguez,Maria Angeles Holgado,C. Sanchez-Lafuente,Antonio M. Rabasco,Adamo Fini +4 more
TL;DR: The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium and the nature of the gelifying cation allow a control of the release rate of the drug.
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Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
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