Journal ArticleDOI
Intracellular trafficking and secretion of inflammatory cytokines
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TLDR
In this paper, the authors provide an overview of the functional plasticity of secretory pathways and their modulation for controlling cytokines and inflammation, and summarize the prevailing knowledge about the trafficking and secretion of individual cytokines.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2013-06-01. It has received 95 citations till now. The article focuses on the topics: Cytokine secretion & Proinflammatory cytokine.read more
Citations
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Macrophage cytokines: involvement in immunity and infectious diseases.
TL;DR: The functions of cytokines secreted by macrophages are discussed, and what is known about their release mechanisms are summarized to delve into how selected pathogens subvert cytokine release for their own survival.
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Hallmarks of Cellular Senescence.
TL;DR: The molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo are described and the importance that these levels of regulations have in the development of therapeutic targets is highlighted.
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Ruchi Kumari,Parmjit S Jat +1 more
TL;DR: In this article, the molecular mechanisms that underlie cellular senescence and the senescent associated growth arrest with a particular focus on why cells stop dividing, the stability of the growth arrest, the hypersecretory phenotype and how the different pathways are all integrated.
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Mast Cell Mediators: Their Differential Release and the Secretory Pathways Involved
TL;DR: This review summarizes the knowledge of MC mediators and will focus on what is known about the discriminatory release of these mediators dependent upon diverse stimuli, MC phenotypes, and species of origin, as well as on the intracellular synthesis, storage, and secretory processes involved.
Journal ArticleDOI
Interleukin-6: an emerging regulator of pathological pain
Ya-Qun Zhou,Zheng Liu,Zhi-Heng Liu,Shu-Ping Chen,Man Li,Allahverdi Shahveranov,Da-Wei Ye,Yu-Ke Tian +7 more
TL;DR: Recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund’s adjuvant injection, and carrageenan injection is summarized.
References
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Journal ArticleDOI
Type 2 diabetes as an inflammatory disease.
TL;DR: Preliminary results from clinical trials with salicylates and interleukin-1 antagonists support the notion that inflammation participates in the pathogenesis of type 2 diabetes and have opened the door for immunomodulatory strategies for the treatment of T2D that simultaneously lower blood glucose levels and potentially reduce the severity and prevalence of the associated complications of this disease.
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The Role of Atg Proteins in Autophagosome Formation
TL;DR: The molecular mechanism of autophagosome formation is described with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagous membrane membrane.
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Rab27a and Rab27b control different steps of the exosome secretion pathway
Matias Ostrowski,Nuno Carmo,Sophie Krumeich,Sophie Krumeich,Isabelle Fanget,Graça Raposo,Graça Raposo,Ariel Savina,Ariel Savina,Catarina Moita,Kristine Schauer,Kristine Schauer,Alistair N. Hume,Rui P. Freitas,Bruno Goud,Bruno Goud,Philippe Benaroch,Philippe Benaroch,Nir Hacohen,Nir Hacohen,Mitsunori Fukuda,Claire Desnos,Miguel C. Seabra,Miguel C. Seabra,Miguel C. Seabra,François Darchen,Sebastian Amigorena,Sebastian Amigorena,Luis F. Moita,Clotilde Théry,Clotilde Théry +30 more
TL;DR: The results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo.
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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
Journal ArticleDOI
Membrane Fusion: Grappling with SNARE and SM Proteins
TL;DR: The two universally required components of the intracellular membrane fusion machinery, SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion and are spectacularly apparent in the exquisite speed and precision of synaptic exocytosis.
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